tailieunhanh - Báo cáo y học: "Prevalence, clinical relevance and characterization of circulating cytotoxic CD4+CD28– T cells in ankylosing spondylitis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Prevalence, clinical relevance and characterization of circulating cytotoxic CD4+CD28– T cells in ankylosing spondylitis. | Arthritis Research Therapy Vol 5 No 5 Duftner et al. Research article Open Access Prevalence clinical relevance and characterization of circulating cytotoxic CD4 CD28- T cells in ankylosing spondylitis Christina Duftner1 Christian Goldberger1 Albrecht Falkenbach2 Reinhard Wurzner3 Barbara Falkensammer3 Karl P Pfeiffer4 Elisabeth Maerker-Hermann5 and Michael Schirmer1 Department of Internal Medicine University of Innsbruck Innsbruck Austria 2Gasteiner Heilstollen Hospital Bad Gastein-Bockstein Austria institute of Hygiene and Social Medicine University of Innsbruck Innsbruck Austria 4Institute of Biostatistics University of Innsbruck Innsbruck Austria 5HSK-Aukammallee Wiesbaden Germany Correspondence M Schirmer e-mail Received 19 Mar 2003 Revisions requested 22 Apr 2003 Revisions received 5 Jun 2003 Accepted 24 Jun 2003 Published 16 Jul 2003 Arthritis Res Ther 2003 5 R292-R300 DOI ar793 2003 Duftner et al. licensee BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 . This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Circulating CD3 CD4 CD28- cells exhibit reduced apoptosis and were found to be more enriched in patients with ankylosing spondylitis than in age-matched healthy control individuals versus P . Levels of CD4 CD28- T cells correlate with disease status as measured using a modified metrology score but they are independent of age and duration of ankylosing spondylitis. CD4 CD28- T cells produce IFN-y and perforin and thus they must be considered proinflammatory and cytotoxic. These T cells share phenotypic and functional properties of natural killer cells strongly expressing CD57 but lacking the lymphocyte marker CD7. MHC class I recognizing and activating natural killer cell receptors on the surface of CD4 CD28- T cells may be .