tailieunhanh - Báo cáo y học: "Put your heart into the joint benefits of statins"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Put your heart into the joint benefits of statins! | Arthritis Research Therapy Vol 5 No 4 Hall Viewpoint Put your heart into the joint benefits of statins Frances C Hall ARC Rheumatology Lecturer Addenbrooke s Hospital Cambridge UK Corresponding author Frances C Hall e-mail fch22@ Received 27 May 2003 Accepted 3 Jun 2003 Published 11 Jun 2003 Arthritis Res Ther 2003 5 202-204 DOI ar788 2003 BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 The recognition that systemic inflammatory diseases are associated with accelerated atherosclerosis offers the prospect of reducing morbidity and mortality of affected patients by attention to traditional cardiovascular risk factors. For example in most studies of mortality in patients with rheumatoid arthritis excess cardiovascular deaths predominate with a risk ratio of about 2 reviewed by Van Doornum 1 . Several recent observations indicate that not only is chronic inflammation associated with atherosclerosis but aberrant cellular and humoral immune responses are integral to its pathogenesis reviewed by Sherer and Shoenfeld 2 . It has become apparent that therapeutic interventions in chronic inflammatory and cardiovascular disease might be closely intertwined. Also emerging is the realisation that agents prescribed as either immunomodulators or lipid modulators might be acting in both capacities. Statins are particularly topical in this regard. Statins 3-hydroxy-3-methylglutaryl-coenzyme A HMG-CoA reductase inhibitors are widely prescribed for individuals at increased risk from cardiovascular disease reviewed by Singh and Mehta 3 . HMG-CoA reductase is an enzyme of the cholesterol biosynthetic pathway that catalyses the conversion of HMG-CoA to mevalonic acid. Downstream metabolites in this pathway include farnesyl pyrophosphate and geranylgeranyl pyrophosphate which are required for post-translational prenylation of a range of moieties including signalling intermediaries tRNA and coenzyme Q in the electron transport chain reviewed in .

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