tailieunhanh - Báo cáo y học: "Hormone replacement therapy in rheumatoid arthritis is associated with lower serum levels of soluble IL-6 receptor and higher insulin-like growth factor 1"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Hormone replacement therapy in rheumatoid arthritis is associated with lower serum levels of soluble IL-6 receptor and higher insulin-like growth factor 1. | Arthritis Research Therapy Vol 5 No 4 Forsblad d Elia et al. Research article Open Access Hormone replacement therapy in rheumatoid arthritis is associated with lower serum levels of soluble IL-6 receptor and higher insulin-like growth factor 1 Helena Forsblad d Elia1 Lars-Ảke Mattsson2 Claes Ohlsson3 Elisabeth Nordborg1 and Hans Carlsten1 1 Department of Rheumatology and Inflammation Research The Sahlgrenska Academy at Goteborg University Goteborg Sweden 2Department of Obstetrics and Gynecology The Sahlgrenska Academy at Goteborg University Goteborg Sweden 3Department of Internal Medicine The Sahlgrenska Academy at Goteborg University Goteborg Sweden Correspondence Helena Forsblad d Elia e-mail Received 18 Oct 2002 Revisions requested 5 Dec 2002 Revisions received 12 Mar 2003 Accepted 21 Mar 2003 Published 1 May 2003 Arthritis Res Ther 2003 5 R202-R209 DOI ar761 2003 Forsblad d Elia et al. licensee BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 . This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Hormone replacement therapy HRT modulates the imbalance in bone remodeling thereby decreasing bone loss. Sex hormones are known to influence rheumatic diseases. The aim of this study was to investigate the effects of HRT on the serum levels of hormones and cytokines regulating bone turnover in 88 postmenopausal women with active rheumatoid arthritis RA randomly allocated to receive HRT plus calcium and vitamin D3 or calcium and vitamin D3 alone for 2 years. An increase in estradiol E2 correlated strongly with improvement of bone mineral density in the hip P and lumbar spine P . Both baseline levels and changes during the study of IL-6 and erythrocyte sedimentation rate were correlated positively P . HRT for 2 years resulted in an increase of the .