tailieunhanh - báo cáo hóa học:" A biregional survey and review of first-line treatment failure and second-line paediatric antiretroviral access and use in Asia and southern Africa"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : A biregional survey and review of first-line treatment failure and second-line paediatric antiretroviral access and use in Asia and southern Africa | TApHOD and leDEA Journal of the International AIDS Society 2011 14 7 http content 14 1 7 JOURNALOF THE INTERNATIONAL AIDS SOCIETY RESEARCH Open Access A biregional survey and review of first-line treatment failure and second-line paediatric antiretroviral access and use in Asia and southern Africa TREAT Asia Pediatric HIV Observational Database TApHOD 1 The International Epidemiologic Databases to Evaluate AIDS IeDEA Southern Africa Paediatric Group2 3 Abstract Background To better understand the need for paediatric second-line antiretroviral therapy ART an ART management survey and a cross-sectional analysis of second-line ART use were conducted in the TREAT Asia Paediatric HIV Observational Database and the IeDEA Southern Africa International Epidemiologic Databases to Evaluate AIDS regional cohorts. Methods Surveys were conducted in April 2009. Analysis data from the Asia cohort were collected in March 2009 from 12 centres in Cambodia India Indonesia Malaysia and Thailand. Data from the IeDEA Southern Africa cohort were finalized in February 2008 from 10 centres in Malawi Mozambique South Africa and Zimbabwe. Results Survey responses reflected inter-regional variations in drug access and national guidelines. A total of 1301 children in the TREAT Asia and 4561 children in the IeDEA Southern Africa cohorts met inclusion criteria for the cross-sectional analysis. Ten percent of Asian and of African children were on second-line ART at the time of data transfer. Median age interquartile range in months at second-line initiation was 120 78-145 months in the Asian cohort and 66 29-112 months in the southern African cohort. Regimens varied and the then current World Health Organization-recommended nucleoside reverse transcriptase combination of abacavir and didanosine was used in less than 5 of children in each region. Conclusions In order to provide life-long ART for children better use of current first-line regimens and broader access to .