tailieunhanh - Báo cáo y học: "Hematopoietic stem cell transplantation for systemic lupus erythematosus"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Hematopoietic stem cell transplantation for systemic lupus erythematosus. | Available online http content 5 5 207 Commentary SLE Hematopoietic stem cell transplantation for systemic lupus erythematosus Richard K Burt and Ann E Traynor Division of Immunotherapy Northwestern University School of Medicine Chicago Illinois USA Correspondence Richard K Burt e-mail rburt@ Received 5 Mar 2003 Accepted 27 May 2003 Published 26 Jun 2003 Arthritis Res Ther 2003 5 207-209 DOI ar786 2003 BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 Abstract Hematopoietic stem cell transplantation was first reported for patients with systemic lupus erythematosus in 1997. The procedure has since been performed worldwide including in Europe in Brazil and in China. A National Institutes of Health-funded phase III clinical trial of hematopoietic stem cell transplantation for refractory systemic lupus erythematosus is anticipated to begin in 2003. Encouraging responses are raising new hope about the role of adult hematopoietic stem cells in systemic lupus erythematosus. Keywords hematopoietic stem cell transplantation lupus Introduction The prognosis of systemic lupus erythematosus SLE markedly improved following the introduction of monthly intravenous pulse cyclophosphamide 500-1000 mg m2 . Nevertheless despite pulse cyclophosphamide and advances in supportive care such as new antihypertensive medications patients with active SLE involving visceral organs have 2-year and 5-year mortalities of approximately 20 and 35 respectively. Since SLE is predominately a disease of young women improvements in disease-related morbidity and mortality were desperately needed. Autologous hematopoietic stem cell transplant regimens for patients with cancer are based on dose escalation of chemotherapeutic drugs that demonstrate effectiveness at standard dosing. Borrowing this concept from the field of oncology we dose escalated cyclophosphamide the most effective antilupus medication to 200mg kg. Also borrowing from experience with a .