tailieunhanh - Báo cáo y học: " Autoantibodies in vasculitis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Autoantibodies in vasculitis | Available online http content 5 3 147 Review Autoantibodies in vasculitis Allan Wiik Department of Autoimmunology Statens Serum Institut Copenhagen Denmark Corresponding author Allan Wiik e-mail aw@ Received 30 Jan 2003 Revisions requested 24 Feb 2003 Revisions received 5 Mar 2003 Accepted 14 Mar 2003 Published 9 Apr 2003 Arthritis Res Ther 2003 5 147-152 DOI ar758 2003 BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 Abstract Before the mid-1980s the only autoantibody widely used to assist in diagnosing vasculitic disease was IgG antibody to the a3 domain of the noncollagenous part of type IV collagen anti-glomerular basement membrane . Since that time antineutrophil cytoplasmic antibodies ANCAs directed at the azurophilic granule proteins proteinase-3 and myeloperoxidase have been established as clinically useful autoantibodies to support a diagnosis of Wegener s granulomatosis microscopic polyangiitis Churg-Strauss syndrome and limited forms of these primary small vessel necrotizing and often granulomatous vasculitides. The establishment of standardized methods for identifying those antibodies was needed before they could be used in clinical practice. The levels of both types of ANCAs tend to increase in parallel with the degree of clinical disease activity and they decrease with successful immunosuppressive therapy. More than one assay may have to be used to discover imminent exacerbations in proteinase-3-ANCA associated syndromes. Although autoantibodies to endothelial cells may be important players in the pathogenesis of several vasculitic conditions they have not gained clinical popularity because of lack of standardized detection methods. Keywords antiendothelial antibodies antineutrophil cytoplasm antibodies prognostics vasculitis Introduction Vasculitis is the term used for inflammatory diseases that involve blood vessel walls and the surrounding interstitium. Vasculitis may affect large medium and small .