tailieunhanh - Báo cáo y học: "α α Upregulated hypoxia inducible factor-1α and -2α pathway in rheumatoid arthritis and osteoarthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: α α Upregulated hypoxia inducible factor-1α and -2α pathway in rheumatoid arthritis and osteoarthritis. | Available online http content 5 4 R193 Research article Open Access Upregulated hypoxia inducible factor-1 a and -2a pathway in rheumatoid arthritis and osteoarthritis Alexandra Giatromanolaki1 Efthimios Sivridis1 Efstratios Maltezos2 Nick Athanassou3 Dimitrios Papazoglou2 Kevin C Gatter3 Adrian L Harris4 and Michael I Koukourakis5 Department of Pathology Democritus University of Thrace Alexandroupolis Greece 2Department of Internal Medicine Democritus University of Thrace Alexandroupolis Greece 3Department of Pathology Nuffield Department of Clinical Laboratory Sciences John Radcliffe Hospital Oxford UK 4Cancer Research UK Molecular Oncology Laboratories Institute of Molecular Medicine John Radcliffe Hospital Oxford UK 5Department of Radiotherapy Oncology Democritus University of Thrace Alexandroupolis Greece Corresponding author Michael I Koukourakis e-mail targ@ Received 20 Dec 2002 Revisions requested 17 Feb 2003 Revisions received 26 Feb 2003 Accepted 10 Mar 2003 Published 29 Apr 2003 Arthritis Res Ther 2003 5 R193-R201 DOI ar756 2003 Giatromanolaki et al. licensee BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 . This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract The pathogenesis of rheumatoid arthritis RA and osteoarthritis OA remains obscure although angiogenesis appears to play an important role. We recently confirmed an overexpression of two angiogenic factors namely vascular endothelial growth factor VEGF and platelet-derived endothelial cell growth factor PD-ECGF by the lining and stromal cells of the synovium in both conditions. Because hypoxia inducible factor HIF -1a and HIF-2a are essential in regulating transcription of the VEGF gene active participation of HIF-a molecules in the pathogenesis of these arthritides is anticipated. We .

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