tailieunhanh - Báo cáo y học: " Systemic lupus erythematosus: a BLySful, yet BAFFling, disorder"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Systemic lupus erythematosus: a BLySful, yet BAFFling, disorder. | Arthritis Research Therapy Vol 5 No 3 Stohl Commentary SLE Systemic lupus erythematosus a BLySful yet BAFFling disorder William Stohl Division of Rheumatology University of Southern California Keck School of Medicine Los Angeles CA USA Corresponding author Williams Stohl e-mail stohl@ Received 13 Feb 2003 Accepted 5 Mar 2003 Published 27 Mar 2003 Arthritis Res Ther 2003 5 136-138 DOI ar755 2003 BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 Abstract BLyS BAFF B-lymphocyte stimulator B-cell activating factor is a vital B-cell survival factor. Overexpression of BLyS in mice may lead to systemic-lupus-erythematosus-like SLE-like disease and BLyS overexpression is common in human SLE. Treatment of SLE-prone mice with a BLyS antagonist ameliorates disease progression and enhances survival making BLyS an attractive therapeutic target in human disease. However several unresolved issues remain including what is the contributory role of APRIL a tumor-necrosis-factor superfamily member related to BLyS in the autoimmunogenic effects of BLyS identification of the optimal BLyS antagonist and identification of those SLE patients most likely to benefit from BLyS antagonist therapy. Keywords APRIL B cells biologic antagonists BLyS BAFF SLE Introduction BLyS B-lymphocyte stimulator also commonly known as BAFF B-cell activating factor is a 285-amino-acid member of the TNF- tumor necrosis factor -ligand superfamily 1-5 . Because the two names are both so common I use them interchangeably throughout this commentary. It is a vital B-cell survival factor 6-8 and mice genetically deficient in BAFF display profound global reductions in mature B cells and in circulating immunoglobulin levels 9 10 . Conversely constitutive overexpression of BAFF in BAFF-transgenic mice leads to expanded B-cell populations and polyclonal hypergammaglobulinemia 5 11 12 . This association between elevated circulating levels of BLyS and polyclonal hypergammaglobulinemia extends to