tailieunhanh - Báo cáo y học: "Functional analysis of an arthritogenic synovial fibroblast"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Functional analysis of an arthritogenic synovial fibroblast. | Arthritis Research Therapy Vol 5 No 3 Aidinis et al. Research article Open Access Functional analysis of an arthritogenic synovial fibroblast Vassilis Aidinis1 David Plows2 Sylva Haralambous2 Maria Armaka1 Petros Papadopoulos1 Maria Zambia Kanaki1 Dirk Koczan3 Hans Juergen Thiesen3 and George Kollias1 institute of Immunology Biomedical Sciences Research Center Alexander Fleming Athens Greece laboratory of Molecular Genetics Hellenic Pasteur Institute Athens Greece 3Institute of Immunology University of Rostock Rostock Germany Corresponding author Vassilis Aidinis and George Kollias e-mail and Received 1 Oct 2002 Revisions requested 18 Oct 2002 Revisions received 13 Feb 2003 Accepted 20 Feb 2003 Published 14 Mar 2003 Arthritis Res Ther 2003 5 R140-R157 DOI ar749 2003 Aidinis et al. licensee BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 . This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Increasing attention has been directed towards identifying nonT-cell mechanisms as potential therapeutic targets in rheumatoid arthritis. Synovial fibroblast SF activation a hallmark of rheumatoid arthritis results in inappropriate production of chemokines and matrix components which in turn lead to bone and cartilage destruction. We have demonstrated that SFs have an autonomous pathogenic role in the development of the disease by showing that they have the capacity to migrate throughout the body and cause pathology specifically to the joints. In order to decipher the pathogenic mechanisms that govern SF activation and pathogenic potential we used the two most prominent methods of differential gene expression analysis differential display and DNA microarrays in a search for deregulated cellular pathways in the arthritogenic SF. Functional clustering of .