tailieunhanh - Báo cáo y học: "Systemic lupus erythematosus and the type I interferon system"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Systemic lupus erythematosus and the type I interferon system. | Arthritis Research Therapy Vol 5 No 2 Ronnblom and Alm Review Systemic lupus erythematosus and the type I interferon system Lars Ronnblom1 and Gunnar V Alm2 Department of Medical Sciences Section of Rheumatology University Hospital Uppsala Sweden 2Department of Veterinary Microbiology Biomedical Center Uppsala Sweden Corresponding author Lars Ronnblom e-mail Received 19 November 2002 Accepted 20 December 2002 Published 20 January 2003 Arthritis Res Ther 2003 5 68-75 DOI ar625 2003 BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 Abstract Patients with systemic lupus erythematosus SLE have ongoing interferon-a IFN-a production and serum IFN-a levels are correlated with both disease activity and severity. Recent studies of patients with SLE have demonstrated the presence of endogenous IFN-a inducers in such individuals consisting of small immune complexes ICs containing IgG and DNA. These ICs act specifically on natural IFN-a-producing cells NIPCs often termed plasmacytoid dendritic cells PDCs . Given the fact that the NIPC PDC has a key role in both the innate and adaptive immune response as well as the many immunoregulatory effects of IFN-a these observations might be important for the understanding of the etiopathogenesis of SLE. In this review we briefly describe the biology of the type I IFN system with emphasis on inducers producing cells especially NIPCs PDCs IFN-a actions and target immune cells that might be relevant in SLE. On the basis of this information and results from studies in SLE patients we propose a hypothesis that explains how NIPCs PDCs become activated and have a pivotal etiopathogenic role in SLE. This hypothesis also indicates new therapeutic targets in this autoimmune disease. Keywords dendritic cells interferon-a lupus systemic lupus erythematosus type I interferon Introduction Systemic lupus erythematosus SLE is a genetically complex autoimmune disease characterized by the occurrence of many