tailieunhanh - báo cáo hóa học:" Cancers in the TREAT Asia HIV Observational Database (TAHOD): a retrospective analysis of risk factors"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Cancers in the TREAT Asia HIV Observational Database (TAHOD): a retrospective analysis of risk factors | Petoumenos et al. Journal of the International AIDS Society 2010 13 51 http content 13 1 51 JOURNALOF THE INTERNATIONAL AIDS SOCIETY RESEARCH Open Access Cancers in the TREAT Asia HIV Observational Database TAHOD a retrospective analysis of risk factors Pafm imonr tc1 ir icif iio I Il li2 MTirnlin iQciA iưiitì ló im2r2C2t n 3 I Iforr1 4 II m Vrinn f i i5 Kathy rcLUumcnus eugenic HUI iNdgdiiiigeswdidiI KUHididSdHiy Stephen J Keil Jun long CHUI Yi-Ming A Chen6 Tuti Merati7 Fujie Zhang8 Poh-Lian Lim9 Somnuek Sungkanuparph10 Sanjay Pujari11 12 13 14 1 1 Sasheela Ponnampalavanar Rosanna Ditangco Christopher KC Lee Andrew Grulich Matthew G Law TREAT Asia HIV Observational Database Abstract Background This retrospective survey describes types of cancers diagnosed in HIV-infected subjects in Asia and assesses risk factors for cancer in HIV-infected subjects using contemporaneous HIV-infected controls without cancer. Methods TREAT Asia HIV Observational Database TAHOD sites retrospectively reviewed clinic medical records to determine cancer diagnoses since 2000. For each diagnosis the following data were recorded date type stage method of diagnosis demographic data medical history and HIV-related information. For risk factor analyses two HIV-infected control subjects without cancer diagnoses were also selected. Cancers were grouped as AIDS-defining cancers ADCs and non-ADCs. Non-ADCs were further categorized as being infection related NADC-IR and unrelated NADC-IUR . Results A total of 617 patients were included in this study 215 cancer cases and 402 controls from 13 sites. The majority of cancer cases were male 71 . The mean age SD for cases was 39 46 and 44 for ADCs NADC-IURs and NADCs-IR respectively. The majority 66 of cancers were ADCs 16 Kaposi sarcoma 40 non-Hodgkin s lymphoma and 9 cervical cancer . The most common NADCs were lung 6 breast 5 and hepatocellular carcinoma and Hodgkin s lymphoma 2 each . There were also three cases