tailieunhanh - báo cáo hóa học:" New diagnostics for tuberculosis: fulfilling patient needs first"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : New diagnostics for tuberculosis: fulfilling patient needs first | Lemaire and Casenghi Journal of the International AIDS Society 2010 13 40 http content 13 1 40 JOURNALOF THE INTERNATIONAL AIDS SOCIETY DEBATE Open Access New diagnostics for tuberculosis fulfilling patient needs first Jean-Frangois Lemaire Martina Casenghi Abstract Background An effective tuberculosis TB control programme requires early diagnosis and immediate initiation of treatment. Any delays in diagnosing TB not only impair a patient s prognosis but also increase the risks of transmitting the disease within the community. Unfortunately the most recent TB diagnostic tools still depend on high-infrastructure laboratories making them poorly adapted for use in resource-limited settings. Additionally existing tests show poor performance in diagnosing TB in children people living with HIV AIDS and extrapulmonary forms of the disease. As a consequence TB patients are still to date left with either fair access to poor diagnostics or poor access to fair diagnostics. Discussion This article discusses recent efforts to identify the minimal test specifications for a new TB point-of-care diagnostic test through an approach based on medical and patient needs. As a first step survey interviews with field practitioners were designed in order to identify the top-priority medical needs in resource-limited settings concerning new TB diagnostics. Subsequently an expert meeting convening field practitioners laboratory experts diagnostic test developers and researchers was held with the objective of defining the minimal test specifications for a new TB point-of-care test that would meet the identified medical needs. Finally gaps in as well as potential solutions for enabling the development of adequate patient needs-driven low-cost new TB diagnostic tests specifically designed for vulnerable populations are discussed. Summary Any new TB point-of-care diagnostic test should be designed to meet minimal specifications satisfying the most urgent medical needs in .