tailieunhanh - báo cáo hóa học:" An acceptability and safety study of the Duet® cervical barrier and gel delivery system in Zimbabwe"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : An acceptability and safety study of the Duet® cervical barrier and gel delivery system in Zimbabwe | Montgomery et al. Journal of the International AIDS Society 2010 13 30 http content 13 1 30 JOURNALOF THE INTERNATIONAL AIDS SOCIETY RESEARCH Open Access An acceptability and safety study of the Duet cervical barrier and gel delivery system in Zimbabwe 1 2 3 1 3 Elizabeth T Montgomery Cynthia Woodsong Petina Musara Helen Cheng Tsungai Chipato Thomas R Moench4 Freya Spielberg1 Ariane van der Straten1 5 Abstract Background Adherence problems with coitally dependent female-initiated HIV prevention methods have contributed to several trials failure to establish efficacy. Continuous use of a cervical barrier with once-daily cleaning and immediate reinsertion may simplify use for women and improve adherence. We assessed the acceptability and safety of precoital and continuous use of the Duet a cervical barrier and gel delivery system in Zimbabwean women. Methods Using a two-arm crossover design with a parallel observation group we randomized 103 women in a 2 2 1 ratio 1 to use the Duet continuously for 14 days followed by a minimum of seven days of washout and then 14 days of precoital use 2 to use the same Duet regimens in reverse order or 3 for observation only. Women were aged 18 to 40 years half were recruited from a pool of previous diaphragm study participants and the other half from the general community. Acceptability and adherence were assessed through an interviewer-administered questionnaire at each of two follow-up visits. Safety was monitored through pelvic speculum exams and report of adverse events. Results The proportion of women who reported consistent Duet use during sex was virtually identical during continuous and precoital regimens vs. . Partner refusal was the most common reason cited for nonuse during sex in both use regimens. Not having the device handy was the most common reason cited for nondaily use in the continuous regimen . Most women were very comfortable using it continuously and inserting it precoitally .