tailieunhanh - báo cáo hóa học:" Male gender predicts mortality in a large cohort of patients receiving antiretroviral therapy in Uganda"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Male gender predicts mortality in a large cohort of patients receiving antiretroviral therapy in Uganda | Mills et al. Journal of the International AIDS Society 2011 14 52 http content 14 1 52 JOURNALOF THE INTERNATIONAL AIDS SOCIETY RESEARCH Open Access Male gender predicts mortality in a large cohort of patients receiving antiretroviral therapy in Uganda 3 3 2 2 4 Edward J Mills Celestin Bakanda Josephine Birungi Keith Chan Robert S Hogg Nathan Ford Jean B Nachega5 6 and Curtis L Cooper7 Abstract Background Because men in Africa are less likely to access HIV AIDS care than women we aimed to determine if men have differing outcomes from women across a nationally representative sample of adult patients receiving combination antiretroviral therapy in Uganda. Methods We estimated survival distributions for adult male and female patients using Kaplan-Meier and constructed multivariable regressions to model associations of baseline variables with mortality. We assessed person-years of life lost up to age 55 by sex. To minimize the impact of patient attrition we assumed a weighted 30 mortality rate among those lost to follow up. Results We included data from 22 315 adults receiving antiretroviral therapy. At baseline men tended to be older had lower CD4 baseline values more advanced disease had pulmonary tuberculosis and had received less treatment follow up all at p . Loss to follow up differed between men and women versus p . Over the period of study men had a significantly increased risk of death compared with female patients adjusted hazard ratio 95 CI p . The crude mortality rate for males differed importantly from females 95 CI 1000 person-years versus 95 CI 1000 person years p . The probability of survival was among males and among females at 12 months. Person-years of life lost was lower for females than males versus per 1000 person-years respectively . Conclusions In order to maximize the benefits of antiretroviral therapy treatment programmes .