tailieunhanh - báo cáo hóa học:" Current status of medication adherence and infant follow up in the prevention of mother to child HIV transmission programme in Addis Ababa: a cohort study"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Current status of medication adherence and infant follow up in the prevention of mother to child HIV transmission programme in Addis Ababa: a cohort study | Mirkuzie et al. Journal of the International AIDS Society 2011 14 50 http content 14 1 50 JOURNALOF THE INTERNATIONAL AIDS SOCIETY RESEARCH Open Access Current status of medication adherence and infant follow up in the prevention of mother to child HIV transmission programme in Addis Ababa a cohort study Alemnesh H Mirkuzie1 2 Sven Gudmund Hinderaker1 Mitike Molla Sisay3 Karen Marie Moland4 and Odd M0rkve1 Abstract Background Prevention of mother to child HIV transmission PMTCT programmes have great potential to achieve virtual elimination of perinatal HIV transmission provided that PMTCT recommendations are properly followed. This study assessed mothers and infants adherence to medication regimen for PMTCT and the proportions of exposed infants who were followed up in the PMTCT programme. Methods A prospective cohort study was conducted among 282 HIV-positive mothers attending 15 health facilities in Addis Ababa Ethiopia. Descriptive statistics bivariate and mulitivariate logistic regression analyses were done. Results Of 282 mothers enrolled in the cohort 232 82 95 CI 77-86 initiated medication during pregnancy 154 64 initiated combined zidovudine ZDV prophylaxis regimen while 78 33 were initiated lifelong antiretroviral treatment ART . In total 171 60 95 CI 55-66 mothers ingested medication during labour. Of the 221 live born infants including two sets of twins 191 87 95 CI 81-90 ingested ZDV and single-dose nevirapine sdNVP at birth. Of the 219 live births twin births were counted once 148 68 95 CI 61-73 mother-infant pairs ingested their medication at birth. Medication ingested by mother-infant pairs at birth was significantly and independently associated with place of delivery. Mother-infant pairs attended in health facilities at birth were more likely OR 95 CI to ingest their medication than those who were attended at home. Overall 189 86 95 CI 80-90 infants were brought for first pentavalent vaccine and 115 52 95 CI 45-58 .