tailieunhanh - báo cáo hóa học:" Low cholesterol? Don't brag yet ... hypocholesterolemia blunts HAART effectiveness: a longitudinal study"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Low cholesterol? Don't brag yet . hypocholesterolemia blunts HAART effectiveness: a longitudinal study | Miguez et al. Journal of the International AIDS Society 2010 13 25 http content 13 1 25 RESEARCH JOURNALOF THE INTERNATIONAL AIDS SOCIETY Open Access Lowlcholesterol Don t brag yet . hypocholesterolemia blunts HAART effectiveness a longitudinal study María Jose Miguez 1 2 John E Lewis3 Vaughn E Bryant3 Rhonda Rosenberg2 Ximena Burbano4 Joel Fishman5 Deshratn Asthana3 Rui Duan2 Nair Madhavan1 and Robert M Malow2 Abstract Background In vitro studies suggest that reducing cholesterol inhibits HIV replication. However this effect may not hold in vivo where other factors such as cholesterol s immunomodulatory properties may interact. Methods Fasting blood samples were obtained on 165 people living with HIV at baseline and after 24 weeks on highly active antiretroviral therapy HAART . Participants were classified as hypocholesterolemic HypoCHL 150 mg dl or non-HypoCHL 150 mg dl and were compared on viro-immune outcomes. Results At baseline participants with HypoCHL 40 exhibited lower CD4 197 181 vs. 295 191 cells mm3 p and CD8 823 448 vs. 1194 598 cells mm3 p counts and were more likely to have detectable viral loads OR p than non-HypoCHL controls. After HAART participants with HypoCHL were twice as likely to experience a virological failure 400 copies 95 CI p and to exhibit 200 CD4 95 CI p compared with non-HypoCHL. Low thymic output was related to poorer CD4 cell response in HypoCHL subjects. Analyses suggest a dose-response relationship with every increase of 50 mg dl in cholesterol related to a parallel rise of 50 CD4 cells. Conclusions The study implicates for the first time HypoCHL with impaired HAART effectiveness including limited CD4 repletion by the thymus and suboptimal viral clearance. Background During the course of HIV disease disturbances of lipid metabolism have been observed long before the introduction of highly active antiretroviral therapy HAART and included hypocholesterolemia HypoCHL .

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