tailieunhanh - báo cáo hóa học:" Planning for pre-exposure prophylaxis to prevent HIV transmission: challenges and opportunities"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Planning for pre-exposure prophylaxis to prevent HIV transmission: challenges and opportunities | Kim et al. Journal of the International AIDS Society 2010 13 24 http content 13 1 24 JOURNALOF THE INTERNATIONAL AIDS SOCIETY MEETING REPORT Open Access Planning for pre-exposure prophylaxis to prevent HIV transmission challenges and opportunities Susan C Kim 1 Stephen Becker2 Carl Dieffenbach3 Blair S Hanewall2 Catherine Hankins4 Ying-Ru Lo5 John W Mellors6 Kevin O Reilly5 Lynn Paxton7 Jason S Roffenbender1 Mitchell Warren8 Peter Piot9 and Mark R Dybul1 10 Abstract There are currently several ongoing or planned trials evaluating the efficacy of pre-exposure prophylaxis PrEP as a preventative approach to reducing the transmission of HIV. PrEP may prove ineffective demonstrate partial efficacy or show high efficacy and have the potential to reduce HIV infection in a significant way. However in addition to the trial results it is important that issues related to delivery implementation and further research are also discussed. As a part of the ongoing discussion in June 2009 the Bill Melinda Gates Foundation sponsored a Planning for PrEP conference with stakeholders to review expected trial results outline responsible educational approaches and develop potential delivery and implementation strategies. The conference reinforced the need for continued and sustained dialogue to identify where PrEP implementation may fit best within an integrated HIV prevention package. This paper identifies the key action points that emerged from the Planning for PrEP meeting. Introduction Recent data suggest that current efforts to prevent and treat HIV are beginning to yield results. Significant expansion of antiretroviral therapy has led to decreased mortality. There has been some stabilization or decline in new HIV infections across several countries in sub-Saharan Africa which is home to 67 of all people living with HIV 1 . Trend data indicate that there were 400 000 fewer new infections in that region in 2008 than there were in 2001 2 . In South Africa .