tailieunhanh - báo cáo hóa học:" Birth outcomes in South African women receiving highly active antiretroviral therapy: a retrospective observational study"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Birth outcomes in South African women receiving highly active antiretroviral therapy: a retrospective observational study | van der Merwe et al. Journal of the International AIDS Society 2011 14 42 http content 14 1 42 JOURNALOF THE INTERNATIONAL AIDS SOCIETY RESEARCH Open Access Birth outcomes in South African women receiving highly active antiretroviral therapy a retrospective observational study I rio nn Hdr K lcmA APica HrmtỸYìan3 i ian Rlavt 2 m-icrcii h4 5 Achrat ia 1 ARA I Ndcri Pddc2 Kalin van del IVIeIWe Risa HCfHlian Vivian Black Matthew Cllelsicil Aslllal Coovadia and Helen Rees Abstract Background Use of highly active antiretroviral therapy HAART a triple-drug combination in HIV-infected pregnant women markedly reduces mother to child transmission of HIV and decreases maternal morbidity. However there remains uncertainty about the effects of in utero exposure to HAART on foetal development. Methods Our objectives were to investigate whether in utero exposure to HAART is associated with low birth weight and or preterm birth in a population of South African women with advanced HIV disease. A retrospective observational study was performed on women with CD4 counts 250 cells mm3 attending antenatal antiretroviral clinics in Johannesburg between October 2004 and March 2007. Low birth weight kg and preterm birth rates 37 weeks were compared between those exposed and unexposed to HAART during pregnancy. Effects of different HAART regimen and duration were assessed. Results Among HAART-unexposed infants 27 60 224 were low birth weight compared with 23 90 388 of early HAART-exposed exposed 28 weeks gestation and 19 76 407 of late HAART-exposed exposed 28 weeks infants p . In the early HAART group a higher CD4 cell count was protective against low birth weight AOR per 50 cells mm3 increase 95 CI p and preterm birth AOR per 50 cells mm3 increase 95 CI p . HAART exposure was associated with an increased preterm birth rate 15 or 138 of 946 versus 5 or seven of 147 in unexposed infants p with early nevirapine and