tailieunhanh - báo cáo hóa học:" Acute retroviral syndrome and high baseline viral load are predictors of rapid HIV progression among untreated Argentinean seroconverters"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Acute retroviral syndrome and high baseline viral load are predictors of rapid HIV progression among untreated Argentinean seroconverters | Socías et al. Journal of the International AIDS Society 2011 14 40 http content 14 1 40 JOURNALOF THE INTERNATIONAL AIDS SOCIETY RESEARCH Open Access Acute retroviral syndrome and high baseline viral load are predictors of rapid HIV progression among untreated Argentinean seroconverters Mn inanD Cf . -f-sr1 2 r Qi ioH2 I 7 1 líar1 3 p I 7i 77 rf 4 I i iif i irr if iCi5 PiTjnid Dr li il 7 6 Eugenid Socids omdi sued iNdtdild Lduiei Ividiid E LdZdio Hoidcio iviingione Ddniel riyluKd f VI r r D m I III7 I Cl z t I I r s 1 VI s r r2 A I I I ri D D I I 7 S r 5 D z Ì I r M 9 Cdilos Remondegui Mdiid I Figuerod Cdrind cesdi Aid Gun Gdbrield lUiK Mdiid B Bouzds Rdvi Kdvdsery Alejdndro KrolewiecKi2 Hector Pérez1 Horacio Sdlomón8 dnd Pedro Cdhn1 2 for Grupo Argentino de Seroconversión Study Group Abstract Background Didgnosis of primdry HIV infection PHI hds important clinicdl dnd public hedlth implicdtions. HAART initidtion dt this stdge remdins controversidl. Methods Our objective wds to identify predictors of disedse progression dmong Argentinedn seroconverters during the first yedr of infection within d multicentre registry of PHI-pdtients didgnosed between 1997 dnd 2008. Cox regression wds used to dndlyze predictors of progression LT-CD4 350 cells mm3 B C events or dedth dt 12 months dmong untredted pdtients. Results Among 134 subjects 74 presented with dcute retrovirdl syndrome ARS . Seven opportunistic infections one dedth nine B events dnd 10 non-AIDS defining serious events were observed. Among the 92 untredted pdtients 24 26 progressed dt 12 months versus three 7 in the tredted group p . The 12-month progression rdte dmong untredted pdtients with ARS wds 34 95 CI versus 13 95 CI in dsymptomdtic pdtients p . In univdridte dndlysis ARS bdseline LT-CD4 350 cells mm3 dnd bdseline dnd six-month virdl lodd VL 100 000 copies mL were dssocidted with progression. In multivdridte dndlysis only ARS dnd bdseline VL 100 000