tailieunhanh - báo cáo hóa học:" Kidney function of HIV-infected children in Lagos, Nigeria: using Filler’s serum cystatin C-based formula"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Kidney function of HIV-infected children in Lagos, Nigeria: using Filler’s serum cystatin C-based formula | Esezobor et al. Journal of the International AIDS Society 2010 13 17 http content 13 1 17 JOURNALOF THE INTERNATIONAL AIDS SOCIETY RESEARCH Open Access Kidney function of HIV-infected children in Lagos Nigeria using Filler s serum cystatin C-based formula 1 1 2 3 z- z- I- 4 Christopher I Esezobor Edna Iroha Olajumoke Oladipo Elizabeth Onifade Oyetunji O Soriyan Adebola O Akinsulie1 Edamisan O Temiye1 Chinyere Ezeaka1 Abstract Background Limited data is available on kidney function in HIV-infected children in sub-Saharan Africa. In addition malnutrition in these children further reduces the utility of diagnostic methods such as creatinine-based estimates of glomerular filtration rate. We determined the serum cystatin C level and estimated glomerular filtration rate of 60 antiretroviral-naive HIV-infected children and 60 apparently healthy age and sex matched children. Methods Serum cystatin C level was measured using enzyme-linked immunosorbent assay technique while glomerular filtration rate was estimated using Filler s serum cystatin C formula. Student t test Mann Whitney U test Pearson chi square and Fisher s exact test were used where appropriate to test difference between groups. Results Compared to the controls the HIV-infected group had significantly higher median interquartile range serum cystatin C levels mg l versus mg l p and a higher proportion of children with serum cystatin C level 1 mg l 10 versus one p . The HIV-infected children had a mean SD eGFR of ml min m2 compared with ml min m2 in the controls p . After controlling for age sex and body mass index only the study group HIV infected versus control remained a significant predictor of serum cystatin C level b p . The proportion of HIV-infected children with eGFR 60 ml min m2 was eight versus none 0 in the control group p . However the serum cystatin C level eGFR and .