tailieunhanh - báo cáo hóa học:" Metabolic and anthropometric parameters contribute to ART-mediated CD4+ T cell recovery in HIV-1-infected individuals: an observational study"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Metabolic and anthropometric parameters contribute to ART-mediated CD4+ T cell recovery in HIV-1-infected individuals: an observational study | Azzoni et al. Journal of the International AIDS Society 2011 14 37 http content 14 1 37 JOURNALOF THE INTERNATIONAL AIDS SOCIETY RESEARCH Open Access Metabolic and anthropometric parameters contribute to ART-mediated CD4 T cell recovery in HIV-1-infected individuals an observational study I ix irs A -7 7C 1Oi1 t A I xrlroll Q Pl I ilbd 2t m otbi c Pim bolocir3 VlonciHio Vici1 i licio I c IC 1. . w1 riotxcrxìp Pldmcrcicc5 Livio Azzoni Andrea S roulkes Cynthia rniniduei Aidiigidii Illi Nigel J Crowther ueborah Glencross 5 5 13 1 Denise Lawrie Wendy Stevens Emmanouil PdpdSdvvds Ian Sdnne and Luis J Montdner Abstract Background The degree of immune reconstitution achieved in response to suppressive ART is associated with baseline individual characteristics such as pre-treatment CD4 count levels of viral replication cellular activation choice of treatment regimen and gender. However the combined effect of these variables on long-term CD4 recovery remains elusive and no single variable predicts treatment response. We sought to determine if adiposity and molecules associated with lipid metabolism may affect the response to ART and the degree of subsequent immune reconstitution and to assess their ability to predict CD1 recovery. Methods We studied a cohort of 69 48 females and 21 males HIV-infected treatment-naive South African subjects initiating antiretroviral treatment d4T 3Tc and lopinavir ritonavir . We collected information at baseline and six months after viral suppression assessing anthropometric parameters dual energy A-ray absorptiometry and magnetic resonance imaging scans serum-based clinical laboratory tests and whole blood-based flow cytometry and determined their role in predicting the increase in CD4 count in response to ART. Results We present evidence that baseline CD4 T cell count viral load CD8 T cell activation CD95 expression and metabolic and anthropometric parameters linked to adiposity LDL HDL cholesterol ratio and waist hip .