tailieunhanh - báo cáo hóa học:" High efficacy of lopinavir/r-based second-line antiretroviral treatment after 24 months of follow up at "

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : High efficacy of lopinavir/r-based second-line antiretroviral treatment after 24 months of follow up at | Ferradini et al. Journal of the International AIDS Society 2011 14 14 http content 14 1 14 JOURNALOF THE INTERNATIONAL AIDS SOCIETY RESEARCH Open Access High efficacy of lopinavir r-based second-line antiretroviral treatment after 24 months of follow up at ESTHER Calmette Hospital in Phnom Penh Cambodia 1 2 4 2 Laurent Ferradini Vara Ouk Olivier Segeral Janin Nouhin Anne Dulioust Chanroeurn Hak IctỉHoIIo Pm Imior5 M lici I omllo3 l lnin4 i in i io2n6 lo n-Pr n nic rìolÌTTỉiccx 3 7 unrl Isabelle Fouiniei Nathalie Leioiie Sopiieak Ngin CHIU vun Mean Jean Fiangois Deniaissy and Eric Nerrienet4 Abstract Background The number of patients on second-line highly active antiretroviral therapy HAART regimens is increasing in resource-limited settings. We describe the outcomes after 24 months for patients on LPV r-based second-line regimens followed up by the ESTHER programme in Phnom Penh Cambodia. Methods Seventy patients who initiated second-line HAART regimens more than 24 months earlier were included and immuno-virological data analyzed. HIV RNA viral load was determined by real-time RT-PCR. HIV-1 drug resistance was interpreted according to the ANRS algorithm. Results Of the 70 patients two were lost to follow up three died and 65 remained on second-line treatment after 24 months of follow up median duration of treatment months . At switch to second-line the median CD4 T cell count was 106 cells mm3 and the median viral load was Log10. Second-line regimens prescribed were ddI 3TC LPV r ddI TDF LPV r ddI AZT LPV r and TDF 3TC LPV r . The median CD4 T cell gain was 258 cells mm3 at 24 months n 63 . After 24 months of follow up 60 65 of the patients presented undetectable viral loads giving an overall treatment success rate of CI in intent-to-treat analysis. Conclusions These data suggest that a LPV r-based second-line regimen is associated with a high rate of virological suppression and immune

TÀI LIỆU LIÊN QUAN
crossorigin="anonymous">
Đã phát hiện trình chặn quảng cáo AdBlock
Trang web này phụ thuộc vào doanh thu từ số lần hiển thị quảng cáo để tồn tại. Vui lòng tắt trình chặn quảng cáo của bạn hoặc tạm dừng tính năng chặn quảng cáo cho trang web này.