tailieunhanh - RESEARCH ON MELANOMA – A GLIMPSE INTO CURRENT DIRECTIONS AND FUTURE TRENDS

Gamma-retroviral vectors, commonly designated retroviral vectors, were the first viral vector employed in Gene Therapy clinical trials in 1990 and are still one of the most used. More recently, the interest in lentiviral vectors, derived from complex retroviruses such as the human immunodeficiency virus (HIV), has been growing due to their ability to transduce non-dividing cells (Lewis et al. 1992; Naldini et al. 1996), an attribute that distinguishes them from other viral vectors, including their simple counterparts, gammaretroviral vectors. Retroviral and lentiviral vectors most attractive features as gene transfer tools include the capacity for large genetic payload (up to 9 kb), minimal patient immune response, high transducing efficiency. | RESEARCH ON MELANOMA -A GLIMPSE INTO CURRENT DIRECTIONS AND FUTURE TRENDS Edited by Mandi Murph Research on Melanoma - A Glimpse into Current Directions and Future Trends Edited by Mandi Murph Published by InTech Janeza Trdine 9 51000 Rijeka Croatia Copyright 2011 InTech All chapters are Open Access articles distributed under the Creative Commons Non Commercial Share Alike Attribution license which permits to copy distribute transmit and adapt the work in any medium so long as the original work is properly cited. After this work has been published by InTech authors have the right to republish it in whole or part in any publication of which they are the author and to make other personal use of the work. Any republication referencing or personal use of the work must explicitly identify the original source. Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published articles. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the use of any materials instructions methods or ideas contained in the book. Publishing Process Manager Petra Nenadic Technical Editor Teodora Smiljanic Cover Designer Jan Hyrat Image Copyright dean bertoncelj 2011. Used under license from First published August 2011 Printed in Croatia A free online edition of this book is available at Additional hard copies can be obtained from orders@ Research on Melanoma - A Glimpse into Current Directions and Future Trends Edited by Mandi Murph p. cm. ISBN 978-953-307-293-7 ikrrr iJ OPEN ACCESS INI Cvn PUBLISHER INTECH open free online editions of InTech Books and Journals can be found at .