tailieunhanh - Báo cáo y học: "Schizophrenia pathophysiology: are we any closer to a complete model"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Schizophrenia pathophysiology: are we any closer to a complete model? | Annals of General Psychiatry BioMed Central Open Access Review Schizophrenia pathophysiology are we any closer to a complete model Shaheen E Lakhan and Karen F Vieira Address Global Neuroscience Initiative Foundation Los Angeles California USA Email Shaheen E Lakhan - slakhan@ Karen F Vieira - kvieira@ Corresponding author Published 15 May 2009 Received II December 2008 Annals of General Psychiatry 2009 8 12 doi 1744-859X-8-12 Accepted 15 May 2009 This article is available from http content 8 I I2 2009 Lakhan and Vieira licensee BioMed Central Ltd This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Schizophrenia a severe brain disorder that involves hallucinations disordered thinking and deficiencies in cognition has been studied for decades in order to determine the early events that lead to this neurological disorder. In this review we interpret the developmental and genetic models that have been proposed and treatment options associated with these models. Schizophrenia was initially thought to be hereditary based on studies of high incidence in certain families. Additionally studies on specific genes such as ZDHHC8 and DTNBPI seem to suggest susceptibility to the onset of this disorder. However no single gene variation has been linked to schizophrenia and recent evidence on sporadic cases of schizophrenia refutes genetics as being a singular cause of the disease. In addition current data suggests neurodevelopmental or environmental causes such as viral infections and prenatal perinatal complications. Before any brain disorder can be understood however multiple cognitive neuroscientific models that accommodate evidence from many biomedical research fields should be considered and .

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