tailieunhanh - Báo cáo y học: "Convulsive liability of bupropion hydrochloride metabolites in Swiss albino mice"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Convulsive liability of bupropion hydrochloride metabolites in Swiss albino mice. | Annals of General Psychiatry BioMed Central Primary research Convulsive liability of bupropion hydrochloride metabolites in Swiss albino mice Peter H Silverstone 1 Robert Williams2 Louis McMahon2 Rosanna Fleming3 and Siobhan Fogarty2 Address 1Biovail Corporation Mississauga Ontario Canada 2Biovail Technologies Ltd Dublin Ireland and Statistical Group Biovail Technologies Ltd Bridgewater NJ USA Email Peter H Silverstone - Robert Williams - rwillia6@ Louis McMahon - mcmahol2@ Rosanna Fleming - rosabfleming@ Siobhan Fogarty - Corresponding author Open Access Published 15 October 2008 Received 16 July 2008 Annals of General Psychiatry 2008 7 19 doi 1744-859X-7-19 Accepted 15 October 2008 This article is available from http content 7 1 19 2008 Silverstone et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background It is known that following chronic dosing with bupropion HCl active metabolites are present in plasma at levels that are several times higher than that of the parent drug but the possible convulsive effects of the major metabolites are not known. Methods We investigated the convulsive liability and dose-response of the three major bupropion metabolites following intraperitoneal administration of single doses in female Swiss albino mice namely erythrohydrobupropion HCl threohydrobupropion HCl and hydroxybupropion HCl. We compared these to bupropion HCl. The actual doses of the metabolites administered to mice n 120 10 per dose group were equimolar equivalents of bupropion HCl 25 50 and 75 mg kg. Post treatment all animals were observed continuously for 2 h during which the number time of