tailieunhanh - báo cáo hóa học:" Long term outcomes of antiretroviral therapy in a large HIV/AIDS care clinic in urban South Africa: a prospective cohort study"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Long term outcomes of antiretroviral therapy in a large HIV/AIDS care clinic in urban South Africa: a prospective cohort study | BioMed Central Journal of the International AIDS Society Open Access Long term outcomes of antiretroviral therapy in a large HIV AIDS care clinic in urban South Africa a prospective cohort study Ian M Sanne 1 Daniel Westreich1 2 Andrew P Macphail1 Dennis Rubel1 Pappie Majuba1 and Annelies Van Rie1 2 Address 1Clinical HIV Research Unit Dept of Medicine University of the Witwatersrand Johannesburg South Africa and 2Department of Epidemiology University of North Carolina Chapel Hill NC USA Email Ian M Sanne - isanne@ Daniel Westreich - westreic@ Andrew P Macphail - pmacphail@ Dennis Rubel - Pappie Majuba - Annelies Van Rie - vanrie@ Corresponding author Published 17 December 2009 Received 7 February 2009 Journal of the International AIDS Society 2009 12 38 doi 1758-2652-12-38 Accepted 17 December 2009 This article is available from http content l2 l 38 2009 Sanne et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Clinical immunologic and virologic outcomes at large HIV AIDS care clinics in resource poor settings are poorly described beyond the first year of highly active antiretroviral treatment HAART . We aimed to prospectively evaluate long-term treatment outcomes at a large scale HIV AIDS care clinic in South Africa. Methods Cohort study of patients initiating HAART between April 1 2004 and March 13 2007 and followed up until April 1 2008 at a public HIV AIDS care clinic in Johannesburg South Africa. We performed time to event analysis on key treatment outcomes and program impact parameters including mortality retention in care CD4 count gain virologic success