tailieunhanh - Gene Transfer Approaches for Gynecological Diseases

Next, I would like to focus on the position of Vice-President, currently held by Dr. Karl Podratz. If we may read the “Bylaws” of IGCS, we find the following: “The Vice-President, in the absence of the President, shall preside at all meetings of the Society and Council and shall have all the powers of President in the event of vacancy in the office of President. S/he shall assist the President in the performance of his/her duties as requested by the President.” This means that the Vice-President is the core of the cabinet. Therefore, I decided to share all information with. | Review Article doi Gene Transfer Approaches for Gynecological Diseases Mari Raki 1 2 Daniel T. Rein 3 and Anna Kanerva1 2 4 Akseli Hemminki1 2 ICancer Gene Therapy Group Rational Drug Design Program University Helsinki 00014 Helsinki Finland 2Department of Oncology and 4Department of Obstetrics and Gynecology Helsinki University Central Hospital 00029 Helsinki Finland 3Department of Obstetrics and Gynecology University of Dusseldorf Medical Center 40001 Dusseldorf Germany To whom correspondence and reprint requests should be addressed at . Box 63 University of Helsinki 00014 Helsinki Finland. Fax 358 9 1912 5465. E-mail . Available online 2 May 2006 Gene transfer presents a potentially useful approach for the treatment of diseases refractory to conventional therapies. Various preclinical and clinical strategies have been explored for treatment of gynecological diseases. Given the direst need for novel treatments much of the work has been performed with gynecological cancers and ovarian cancer in particular. Although the safety of many approaches has been demonstrated in early phase clinical trials efficacy has been mostly limited so far. Major challenges include improving gene transfer vectors for enhanced and selective delivery and achieving effective penetration and spread within advanced and complex tumor masses. This review will focus on current and developmental gene transfer applications for gynecological diseases. Key Words gene transfer gene therapy ovarian cancer cervical cancer gynecological disease Contents Introduction. 154 Gene Therapy for Ovarian Cancer. 154 Targeting Vectors to Ovarian Cancer Cells. 155 Replacement of an Altered Tumor Suppressor Gene. 155 Inhibition of Growth Factor Receptors. 157 Molecular Chemotherapy. 157 Antiangiogenic Gene Therapy. 157 Virotherapy. 158 Gene Therapy for Other Gynecological Cancers. 159 Gene Therapy for Other Gynecological Disorders. 159 Future Directions.