tailieunhanh - Báo cáo khoa học: Inhibition of PI3K/Akt partially leads to the inhibition of PrPC-induced drug resistance in gastric cancer cells

Cellular prion protein (PrP C ), a glycosyl-phosphatidylinositol-anchored membrane protein with unclear physiological function, was previous found to be upregulated in adriamycin (ADR)-resistant gastric carcinoma cell line SGC7901/ADR compared to its parental cell line SGC7901. | Inhibition of PI3K Akt partially leads to the inhibition of PrPC-induced drug resistance in gastric cancer cells Jie Liang Fulin Ge Changcun Guo Guanhong Luo Xin Wang Guohong Han Dexin Zhang Jianhong Wang Kai Li Yanglin Pan Liping Yao Zhanxin Yin Xuegang Guo Kaichun Wu Jie Ding and Daiming Fan State Key Laboratory of Cancer Biology and Xijing Hospitalof Digestive Diseases Fourth Military MedicalUniversity Xi an Shaanxi China Keywords drug resistance gastric cancer P-gp PI3K Akt prion protein Correspondence J. Ding State Key Laboratory of Cancer Biology and Xijing Hospitalof Digestive Diseases Fourth Military MedicalUniversity Xi an 710032 China Fax 86 29 82539041 Tel 86 29 84771504 E-mail dingjie@ D. Fan State Key Laboratory of Cancer Biology and Xijing Hospitalof Digestive Diseases Fourth Military MedicalUniversity Xi an 710032 China Fax 86 29 82539041 Tel 86 29 84775221 E-mail fandaim@ These authors contributed equally to this work Received 1 October 2008 revised 16 November 2008 accepted 24 November 2008 doi Cellular prion protein PrPC a glycosyl-phosphatidylinositol-anchored membrane protein with unclear physiological function was previous found to be upregulated in adriamycin ADR -resistant gastric carcinoma cell line SGC7901 ADR compared to its parental cell line SGC7901. Overexpression of PrPC in gastric cancer has certain effects on drug accumulation through upregulation of P-glycoprotein P-gp which is suggested to play an important role in determining the sensitivity of tumor cells to chemotherapy and is linked to activation of the phosphatidylinositol-3-kinase Akt PI3K Akt pathway. In the present study we further investigate the role of the PI3K Akt pathway in PrPC-induced multidrug-resistance MDR in gastric cancer. Immunohistochemistry and confocal microscope detection suggest a positive correlation between PrPC and phosphorylated Akt p-Akt expression in gastric cancer. Using established stable PrPC

• Báo cáo khoa học
• medical reports
• thesis report
• traditional medicine
• medicine
• cell proliferation
• oxidation
• Selective Oxidation
• Gold Nanoparticles
• Aerobic Oxidation
• Oxidation Catalysts
• Crystalline Materials
• Molecular Oxygen
• Nuclear engineering and technology
• The recycling of nuclear graphite after micro oxidation
• Nuclear graphite after micro oxidation
• Whether ground micro oxidation graphite
• The oxidized graphite particles
• The recycling of nuclear graphite
• Dietary fructose
• Fatty acid oxidation
• Hepatic steatosis
• Fatty acid β oxidation
• Lipid oxidation
• Meal extracts
• Refined soybean oil
• Total oxidation value
• Meal extracts on retarding lipid oxidation
• Environmental advances
• Volatile organic compounds
• Ozone oxidation technique
• Catalytic ozone oxidation
• Ozone oxidation
• Scientific reports
• breast cancer
• disorders
• Fatty acid
• Vietnam Journal of Science and Technology
• Masterbatch containing anti oxidation additive
• Anti oxidation master batch
• Melt flow index
• Tensile strength and elongation
• Vietnam Journal of Chemistry
• Mg Al MoO4 layered double hydroxides
• Catalysts for the oxidation of styrene
• The oxidation of styrene
• The synthesized solids showed the layered hydroxide structure
• Effects of ascorbic acid treatment
• Packaging method on lipid oxidation
• Frozen storage
• Ascorbic acid
• Vacuum packaging
• Lipid oxidation
• CO oxidation
• Manganese oxides
• Binary catalysts
• Formic acid oxidation
• Novel binary catalysts
• Thermal spray
• NiCr Al duplex coating
• Oxidation resistance
• Carbon steel substrate
• High temperature oxidation resistant
• High temperature working parts
• High temperature steam oxidation kinetics
• High temperature oxidation
• Weight gain measurements
• E110 cladding tubes material
• Copper oxide
• Thin films
• Thermal oxidation
• Annealing temperature
• Thermal oxidation method
• X ray diffraction measurement
• Journal of Chemistry
• Aftertreatment systems
• Diesel oxidation catalyst
• Bimetallic catalyst
• Commercial monolith
• Journal of Science and Technology
• Plasma electrolytic oxidation coating
• 6061 Al alloy
• Electrolyte without alkali ions
• Plasma electrolytic oxidation
• Porous nickel
• Cast nickel
• Duplex macrostructure
• Inward migration
• Linear kinetics
• Redox process
• Oxidation reduction reactions
• Oxidation reduction reactions in geochemistry
• Extremely reducing or oxidizing conditions
• Reduction potentials in geochemistry
• Benzyl alcohol oxidation
• Peripherally 1 2 dinaphthyl ethanediol
• Phthalocyanine complexes
• UV Vis light absorption
• Catalytic oxidation
• polyamine
• oxidase K300M
• Report medicine
• Crystal structure
• bacteria
• scientific research
• biochemistry
• hemoglobin
• biopreservation
• cytoplasm
• chemical reaction
• tumor cells