tailieunhanh - Báo cáo khoa học: SREBPs: SREBP function in glia–neuron interactions

The mammalian nervous system is relatively autonomous in lipid metabolism. In particular, Schwann cells in the peripheral nervous system, and oligodendrocytes and astrocytes in the central nervous system, are highly active in lipid synthesis. | MINIREVIEW SREBPs SREBP function in glia-neuron interactions Nutabi Camargo August B. Smit and Mark H. G. Verheijen Department of Molecular and Cellular Neurobiology Center for Neurogenomics and Cognitive Research Neuroscience Campus Amsterdam VU University Amsterdam The Netherlands Keywords astrocyte cholesterol fatty acid glia lipid metabolism myelin neuron Schwann cell SREBP synapse Correspondence M. H. G. Verheijen Department of Molecular and Cellular Neurobiology Center for Neurogenomics and Cognitive Research VU University Amsterdam Neuroscience Campus Amsterdam De Boelelaan 1085 1081 HV Amsterdam The Netherlands Fax 31 20 598 9281 Tel 31 20 598 7120 E-mail The mammalian nervous system is relatively autonomous in lipid metabolism. In particular Schwann cells in the peripheral nervous system and oligodendrocytes and astrocytes in the central nervous system are highly active in lipid synthesis. Previously enzymatic lipid synthesis in the liver has been demonstrated to be under the control of the sterol regulatory element-binding protein SREBP transcription factors. Here we put forward the view that SREBP transcription factors in glia cells control the synthesis of lipids involved in various glia-neuron interactions thereby affecting a range of neuronal functions. This minireview compiles current knowledge on the involvement of Schwann cell SREBPs in myelination of axons in the peripheral nervous system and proposes a role for astrocyte SREBPs in neuronal functioning in the central nervous system. Received 28 August 2008 accepted 10 October 2008 doi Introduction The sterol regulatory element-binding proteins SREBPs belong to the family of basic helix-loop-helix leucine zipper transcription factors which are known to regulate lipid metabolism in liver and adipose tissue. The SREBP family consists of SREBP-1a SREBP-lc and SREBP-2 1 . SREBP-lc and SREBP-2 preferentially govern the upregulation of genes .