tailieunhanh - Báo cáo y học: "Alcohol significantly lowers the seizure threshold in mice when co-administered with bupropion hydrochloride"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Alcohol significantly lowers the seizure threshold in mice when co-administered with bupropion hydrochloride. | Annals of General Psychiatry BioMed Central Primary research Alcohol significantly lowers the seizure threshold in mice when co-administered with bupropion hydrochloride Peter H Silverstone 1 Robert Williams2 Louis McMahon2 Rosanna Fleming3 and Siobhan Fogarty2 Open Access Address Clinical Affairs Biovail Corporation Mississauga Ontario Canada 2Research and Development Biovail Technologies Ltd. Dublin Ireland and 3Statistical Group Biovail Technologies Ltd. Bridgewater New Jersey USA Email Peter H Silverstone - Robert Williams - rwilliams@ Louis McMahon - mcmahol2@ Rosanna Fleming - rosabfleming@ Siobhan Fogarty - sfogarty@ Corresponding author Published 18 August 2008 Received 28 November 2006 Accepted 18 August 2008 Annals of General Psychiatry 2008 7 11 doi l744-859X-7-l I This article is available from http content 7 l ll 2008 Silverstone et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Bupropion HCl is a widely used antidepressant that is known to cause seizures in a dose-dependent manner. Many patients taking antidepressants will consume alcohol even when advised not to. Previous studies have not shown any interactions between bupropion HCl and alcohol. However there have been no previous studies examining possible changes in seizure threshold induced by a combination of alcohol and bupropion HCl. Methods Experimentally naive female Swiss albino mice l0 per group received either single doses of bupropion HCl ranging from 100 mg kg to 120 mg kg or vehicle NaCl by intraperitoneal IP injection in a dose volume of l0 ml kg and single-dose ethanol alone g kg or vehicle 5 min prior .