tailieunhanh - báo cáo hóa học:" Nonopportunistic Neurologic Manifestations of the Human Immunodeficiency Virus: An Indian Study"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Nonopportunistic Neurologic Manifestations of the Human Immunodeficiency Virus: An Indian Study | Journal of the International AIDS Society BioMed Central Research article Nonopportunistic Neurologic Manifestations of the Human Immunodeficiency Virus An Indian Study Alaka K Deshpande 1 and Mrinal M Patnaik2 Address 1Professor and Head Department of Retroviral Medicine Grant Medical College Sir JJ Group of Hospitals Mumbai India and 2Chief Resident Department of Retroviral Medicine Grant Medical College Sir JJ Group of Hospitals Mumbai India Email Alaka K Deshpande - alakadeshpande@ Corresponding author Open Access Published 4 October 2005 Journal of the International AIDS Society 2005 7 2 This article is available from http content 7 4 2 Abstract Context HIV-1 is a neurotropic virus. In a resource-limited country such as India large populations of affected patients now have access to adequate chemoprophylaxis for opportunistic infections OIs allowing them to live longer. Unfortunately the poor availability of highly active antiretroviral therapy HAART has allowed viral replication to proceed unchecked. This has resulted in an increase in the debilitating neurologic manifestations directly mediated by the virus. Objective The main objective of this study was to identify and describe in detail the direct neurologic manifestations of HIV-1 in antiretroviral treatment ART -naive HIV-infected patients excluding the neurologic manifestations produced by opportunistic pathogens . Design Three hundred successive cases of HIV-1 infected ART-naive patients with neurologic manifestations were studied over a 3-year period. Each case was studied in detail to identify and then exclude manifestations due to opportunistic pathogens. The remaining cases were then analyzed specially in regard to their occurrence and the degree of immune suppression CD4 cell counts . Setting and Patients The study was carried out in an apex tertiary referral care center for HIV AIDS in India. All patients were admitted for a detailed analysis. No interventions .