tailieunhanh - báo cáo hóa học:" Evaluation of early atherosclerotic findings in women with polycystic ovary syndrome"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Evaluation of early atherosclerotic findings in women with polycystic ovary syndrome | Mohammadi et al. Journal of Ovarian Research 2011 4 19 http content 4 1 19 JOURNAL OF OVARIAN RESEARCH RESEARCH Open Access Evaluation of early atherosclerotic findings in women with polycystic ovary syndrome Afshin Mohammadi1 Mohammadreza Aghasi2 Leila Jodeiry-farshbaf3 Shaker Salary-Lac4 and Mohammad Ghasemi-rad5 Background Polycystic ovary syndrome PCOS is the most common endocrinopathy in women of childbearing age and it seems better to consider it as an ovarian manifestation of metabolic syndrome. The aim of the current study was to evaluate early atherosclerotic findings in patients with PCOS. Methods We enrolled 46 women with PCOS and 45 normal control subjects who were referred to our hospital s endocrinology outpatient clinic. Carotid intima media thickness CIMT and flow-mediated dilatation FMD were performed in both cases and matched controls. Results Patients with PCOS showed an increased mean CIMT mm when compared with the control subjects mm . This difference was statistically significant p . The mean FMD in young patients with PCOS was while it was in normal subjects. This difference was also statistically significant p . Conclusion Our findings suggest that PCOS is related with early atherosclerotic findings. Background Polycystic ovary syndrome PCOS is the most common endocrinopathy in women of childbearing age and it seems better to consider it as an ovarian manifestation of metabolic syndrome MS 1 2 . MS has already been confirmed as part of the tsunami of cardiovascular risk factors obesity lipid abnormalities impaired glucose tolerance and hypertension 3 . Insulin resistance is considered as the basic pathophysiological mechanism in MS and is also a well-recognised presentation of PCOS 4 . However data regarding endothelial function impairment as an indicator of increased risk of cardiovascular disease in PCOS are still controversial 5 6 with some studies saying that .