tailieunhanh - Báo cáo y học: "Serum glutamine, set-shifting ability and anorexia nervosa"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Serum glutamine, set-shifting ability and anorexia nervosa. | Nakazato et al. Annals of General Psychiatry 2010 9 29 http content 9 1 29 ANNALS OF GENERAL PSYCHIATRY PRIMARY RESEARCH Open Access Serumlglutamine set-shifting ability and anorexia nervosa Michiko Nakazato 1 2 Kenji Hashimoto3 Ulrike Schmidt1 Kate Tchanturia1 Iain C Campbell1 David A Collier4 Masaomi Iyo2 5 and Janet Treasure6 Abstract Background Set-shifting is impaired in people with anorexia nervosa AN but the underlying physiological and biochemical processes are unclear. Animal studies have established that glutamatergic pathways in the prefrontal cortex play an important role in set-shifting ability. However it is not yet understood whether levels of serum glutamatergic amino acids are associated with set-shifting performance in humans. The aim of this study was to determine whether serum concentrations of amino acids related to glutamatergic neurotransmission glutamine glutamate glycine L-serine D-serine are associated with set-shifting ability in people with acute AN and those after recovery. Methods Serum concentrations of glutamatergic amino acids were measured in 27 women with current AN AN group 18 women recovered from AN ANRec group and 28 age-matched healthy controls HC group . Set-shifting was measured using the Wisconsin Card Sorting Test WCST and the Trail Making Task TMT . Dimensional measures of psychopathology were used including the Eating Disorder Examination Questionnaire EDEQ the Maudsley Obsessive-Compulsive Inventory MOCI and the Hospital Anxiety and Depression Scale HADS . Results Serum glutamine concentrations in the AN group 1 pM mean SD were significantly higher by approximately 20 than those in the HC group 1 pM mean SD F 2 70 P 95 CI to . Concentrations of serum glutamine were positively associated with markers of the illness severity a negative correlation was present between serum glutamine concentrations and body mass index BMI and lowest BMI and a .

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