tailieunhanh - báo cáo hóa học:" Longitudinal monitoring of CA125 levels provides additional information about survival in ovarian cancer"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Longitudinal monitoring of CA125 levels provides additional information about survival in ovarian cancer | Gupta et al. Journal of Ovarian Research 2010 3 22 http content 3 1 22 RESEARCH JOURNAL OF OVARIAN RESEARCH Open Access Longitudinal monitoring of CA125 levels provides additional information about survival in ovarian cancer Digant Gupta Carolyn A Lammersfeld Pankaj G Vashi Donald P Braun Abstract Background We investigated the prognostic impact of changes in serum CA125 levels during the first 3 months of therapy in ovarian cancer. Methods A case series of 170 ovarian cancer patients treated at Cancer Treatment Centers of America. Based on CA125 levels at baseline and 3 months patients were classified into 4 groups 1 Normal 0-35 U ml at baseline and three months 2 High 35 U ml at baseline normal at three months 3 Normal at baseline high at 3 months 4 High at baseline and three months. Kaplan Meier method was used to calculate survival across the 4 categories. Results Of 170 patients 36 were newly diagnosed while 134 had received prior treatment. 25 had stage I disease at diagnosis 15 stage II 106 stage III and 14 stage IV. The median age at presentation was years range - years . At baseline 31 patients had normal 0-35 U ml serum CA125 levels while 139 had high 35 U ml levels. At 3 months 59 had normal while 111 had high levels. Patients with a reduced CA125 at 3 months had a significantly better survival than those with increased CA125 at 3 months. Patients with normal values of CA125 at both baseline and 3 months had the best overall survival. Conclusions These data show that reduction in CA125 after 3 months of therapy is associated with better overall survival in ovarian cancer. Patients without a significant decline in CA125 after 3 months of therapy have a particularly poor prognosis. Background Ovarian cancer is the second most common gynecologic malignancy in the United States with approximately 22 200 new cases each year 1 . It is also the leading cause of death from gynecologic cancers in the United States 2 . The .

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