tailieunhanh - Upper Gastrointestinal Surgery - part 10

Thực quản bắt nguồn từ hai nguồn mô khác nhau, tức là những mái vòm thuộc về mang cá và túi họng bằng miệng và các trung bì nội tạng aborally. Cả hai tham gia trong phát triển phôi thai và thai | Table . Randomised trials of preoperative chemoradiotherapy and surgery vs surgery alone in resectable oesophageal carcinoma Trial Randomisation No. Histology Radiotherapy Chemotherapy Resection Rate Postoperative Mortality PCR Median Survival months 2-year Survival 3-year Survival see Adeno Nygaard et al CRT S 47 47 0 35 Gy Cis Bleo 66 24 NS 7 23 17 13 Chemo s 50 50 0 Nil Cis Bleo 58 15 NS 6 6 3 RT S 48 48 0 35 Gy Nil 54 11 NS 10 25 21 s only 41 41 0 Nil Nil 68 13 - 6 p 03 13 9 Le Prise et al CRT S 41 41 0 20 Gy Cis 5FU 85 8 10 10 27 19 14 s only 45 45 0 Nil Nil 84 7 - 11 p 33 14 Apinop et al CRT S 35 35 0 40 Gy Cis 5FU 74 12 20 30 26 15 s only 34 34 0 Nil Nil 100 15 - p 23 20 Walsh etal CRT S 58 0 58 40 Gy Cis 5FU 90 10 22 16 37 32 16 s only 55 0 55 Nil Nil 100 4 - 11 p 26 6 Bosset etal CRT S 143 143 0 37 Gy Cis 78 12 20 48 36 17 s only 139 139 0 Nil Nil 68 4 - p 42 34 Urba etal 18 CRT S 50 13 37 45 Gy Cis 5FU Vinblast 90 2 28 40 30 s only 50 12 38 Nil Nil 90 0 - p 34 16 Burmeister etal 19 CRT S s only 128 128 92 157 35 Gy Nil Cis 5FU Nil NS NS NS NS NS NS see squamous cell carcinoma Adeno adenocarcinoma PCR pathological complete response CRT chemoradiotherapy s surgery Chemo chemotherapy RT radiotherapy Cis Cisplatin Bleb bleomycin NS not stated 5FU fluorouracil Vinblast vinblastin mixed undifferentiated. Table . Recent randomised trials of definitive chemoradiotherapy versus radiotherapy in unresectable oesophageal carcinoma Trial Randomisation No. of patients Adeno Radiotherapy Chemotherapy Median survival months 2-year survival 3-year survival 5-year survival total see Araujo etal 24 CRT 28 28 0 50 Gy Bleo Mito Cis 15 38 22 16 RT 31 31 0 same Nil 15 p 22 12 6 Roussel etal 25 CRT no no 0 40 Gy Cis 20 NS 8 4-year RT 111 111 0 same Nil p 16 NS 10 4-year Smith etal 23 CRT 59 59 0 40-60 Gy Mito 5FU NS 27 9 RT 60 60 0 same Nil p NS 12 7 Herskovic 9 CRT