tailieunhanh - báo cáo hóa học:" Bcl-2 expression is altered with ovarian tumor progression: an immunohistochemical evaluation"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Bcl-2 expression is altered with ovarian tumor progression: an immunohistochemical evaluation | Journal of Ovarian Research BioMed Central Research Bcl-2 expression is altered with ovarian tumor progression an immunohistochemical evaluation Nicole S Anderson1 Leslie Turner1 Sandra Livingston1 Ren Chen2 Santo V Nicosia1 3 and Patricia A Kruk 1 3 Open Access Address Department of Pathology and Cell Biology University of South Florida Tampa FL 33612 USA 2Office of Clinical Research University of South Florida Tampa FL 33612 USA and 3H. Lee Moffitt Cancer Center and Research Institute Tampa FL 33612 USA Email Nicole S Anderson - nanderso@ Leslie Turner - lpassmor@ Sandra Livingston - slivings@ Ren Chen - rchen@ Santo V Nicosia - snicosia@ Patricia A Kruk - pkruk@ Corresponding author Published 25 October 2009 Received 19 June 2009 Journal of Ovarian Research 2009 2 16 doi l757-22l5-2-l6 Accepted 25 October 2009 This article is available from http content 2 l l6 2009 Anderson et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Ovarian cancer is the most lethal gynecologic malignancy. The ovarian tumor microenvironment is comprised of tumor cells surrounding stroma and circulating lymphocytes an important component of the immune response in tumors. Previous reports have shown that the anti-apoptotic protein Bcl-2 is overexpressed in many solid neoplasms including ovarian cancers and contributes to neoplastic transformation and drug-resistant disease resulting in poor clinical outcome. Likewise studies indicate improved clinical outcome with increased presence of lymphocytes. Therefore we sought to examine Bcl-2 expression in normal benign and cancerous ovarian tissues to determine the .