tailieunhanh - báo cáo hóa học:" Emerging role of microRNAs in diagnosis and treatment of various diseases including ovarian cancer"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Emerging role of microRNAs in diagnosis and treatment of various diseases including ovarian cancer | Journal of Ovarian Research BioMed Central Open Access Emerging role of microRNAs in diagnosis and treatment of various diseases including ovarian cancer Parag P Shah Lauren E Hutchinson and Sham S Kakar Address Department of Physiology and Biophysics James Graham Brown Cancer Center University of Louisville Louisville. KY 40202 USA Email Parag P Shah - ppshah04@ Lauren E Hutchinson - lehutc01@ Sham S Kakar - sskaka01@ Corresponding author Published 27 August 2009 Received 27 July 2009 Journal of Ovarian Research 2009 2 11 doi 1757-2215-2-11 Accepted 27 August 2009 This article is available from http content 2 1 11 2009 Shah et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract MicroRNAs miRNAs represent a class of small non-coding RNAs that control gene expression by targeting messenger RNA mRNA . Recently it has been demonstrated that miRNA expression is altered in many human diseases including cancers suggesting that miRNA may play a potential role in the pathogenesis of different diseases. It has also been reported that there is a unique expression pattern of miRNAs in the disease state differing from the normal state. In this review we focus on the miRNA signatures in different human diseases including cancers. Such signatures may be used as diagnostic and prognostic markers. Discovery of microRNA Discovered in 1993 from nematode Caenorhabditis elegans miRNA are small non-coding RNAs composed of 18-24 nucleotides. They act by negatively regulating gene expression at the post-transcriptional level through modulation of mRNA expression. Lee et al. 1 found that lin-4 an important gene that is important for post-embryonic .