tailieunhanh - báo cáo hóa học:" BMP-2 signaling in ovarian cancer and its association with poor prognosis"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : BMP-2 signaling in ovarian cancer and its association with poor prognosis | Journal of Ovarian Research BioMed Central Open Access BMP-2 signaling in ovarian cancer and its association with poor prognosis Cécile Le Page1 Marie-Line Puiffe1 Liliane Meunier1 Magdalena Zietarska1 Manon de Ladurantaye1 Patricia N Tonin2 3 Diane Provencher1 4 and Anne-Marie Mes-Masson 1 5 Address 1Centre de recherche du Centre Hospitalier de 1 Université de Montréal CR CHUM Institut du cancer de Montréal Montréal Canada departments of Human Genetics and Medicine McGill University Canada 3The Research Institute of the McGill University Health Centre Montréal Canada 4Départment de gynécologie et obstétrique Université de Montréal Montreal QC Canada and 5Départment de Médicine Université de Montréal Montréal Montréal Canada Email Cécile Le Page - cecilelepage@ Marie-Line Puiffe - marielinepuiffe@ Liliane Magdalena Zietarska - bmagda@ Manon de Ladurantaye - madel13@ Patricia N Tonin - Diane Provencher - Anne-Marie Mes-Masson - Corresponding author Published 14 April 2009 Received 15 December 2008 Journal of Ovarian Research 2009 2 4 doi 1757-2215-2-4 Accepted 14 April 2009 This article is available from http content 2 1 4 2009 Le Page et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background We previously observed the over-expression of BMP-2 in primary cultures of epithelial ovarian cancer EOC cells as compared to normal epithelial cells based on Affymetrix microarray profiling 1 . Here we investigate the effect of BMP-2 on several parameters of ovarian cancer tumorigenesis using the TOV-2223 TOV-1946 and TOV-112D .