tailieunhanh - MELANOMA IN THE CLINIC – DIAGNOSIS, MANAGEMENT AND COMPLICATIONS OF MALIGNANCY

Retroviral vectors have gained an increasing value in gene therapy because they stably deliver therapeutic genes to the host cell genome. These therapeutic genes are supposed to rectify consequences of inherited and acquired mutated genes in the host cell genome, or alter host cell function to cure diseases. In the following section we will discuss the biology and life cycle of retroviruses which starts with viral entry into the host cell, reverse transcription of viral RNA, nuclear import of the provirus, and finally integration of viral DNA into the cell host genome (Flint, Racaniello et al. 2004) | MELANOMA IN THE CLINIC - DIAGNOSIS management AND COMPLICATIONS OF MALIGNANCY Edited by Mandi Murph Melanoma in the Clinic - Diagnosis Management and Complications of Malignancy Edited by Mandi Murph Published by InTech Janeza Trdine 9 51000 Rijeka Croatia Copyright 2011 InTech All chapters are Open Access articles distributed under the Creative Commons Non Commercial Share Alike Attribution license which permits to copy distribute transmit and adapt the work in any medium so long as the original work is properly cited. After this work has been published by InTech authors have the right to republish it in whole or part in any publication of which they are the author and to make other personal use of the work. Any republication referencing or personal use of the work must explicitly identify the original source. Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published articles. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the use of any materials instructions methods or ideas contained in the book. Publishing Process Manager Petra Nenadic Technical Editor Teodora Smiljanic Cover Designer Jan Hyrat Image Copyright Andresr 2010. Used under license from First published July 2011 Printed in Croatia A free online edition of this book is available at Additional hard copies can be obtained from orders@ Melanoma in the Clinic - Diagnosis Management and Complications of Malignancy Edited by Mandi Murph p. cm. ISBN 978-953-307-571-6 ikrrr iJ OPEN ACCESS INI Cvn PUBLISHER INTECH open free online editions of InTech Books and Journals can be found at .