tailieunhanh - BRAIN TUMORS CURRENT AND EMERGING THERAPEUTIC STRATEGIES

The major pathogenic mechanism of poststreptococcal glomerulonephritis (PSGN) is an in situ immune complex formation due to deposition of streptococcal nephritogenic antigens, such as nephritis-associated plasmin receptor (NAPlr) and Streptococcal pyrogenic exotoxin B (SPE B). Both are capable of activating the alternate pathway of the complement cascade and enhance the expression of adhesion molecules. SPE B also stimulates the production of chemotactic cytokines. NAPlr was isolated from group A streptococcus and was shown to bind plasmin(ogen). In the original report, 92 percent of Japanese patients with the acute PSGN had anti-NAPlr antibodies, and about 80% of renal biopsy samples showed deposits of NaPlr | BRAIN TUMORS -CURRENT AND EMERGING THERAPEUTIC STRATEGIES Edited by Ana Lucia Abujamra Brain Tumors - Current and Emerging Therapeutic Strategies Edited by Ana Lucia Abujamra Published by InTech Janeza Trdine 9 51000 Rijeka Croatia Copyright 2011 InTech All chapters are Open Access articles distributed under the Creative Commons Non Commercial Share Alike Attribution license which permits to copy distribute transmit and adapt the work in any medium so long as the original work is properly cited. After this work has been published by InTech authors have the right to republish it in whole or part in any publication of which they are the author and to make other personal use of the work. Any republication referencing or personal use of the work must explicitly identify the original source. Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published articles. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the use of any materials instructions methods or ideas contained in the book. Publishing Process Manager Iva Simcic Technical Editor Teodora Smiljanic Cover Designer Jan Hyrat Image Copyright dusan964 2010. Used under license from First published August 2011 Printed in Croatia A free online edition of this book is available at Additional hard copies can be obtained from orders@ Brain Tumors - Current and Emerging Therapeutic Strategies Edited by Ana Lucia Abujamra p. cm. ISBN 978-953-307-588-4 ikrrr iJ OPEN ACCESS INI Cvn PUBLISHER INTECH open free online editions of InTech Books and Journals can be found at .