tailieunhanh - AUTISM SPECTRUM  DISORDERS – FROM GENES TO ENVIRONMENT  

The complement system is an important mediator of tissue inflammation and injury. It is a family of more than 20 serum and cell-surface proteins and they operate as a cascade of reactions. The IgG immune complexes bind to complement factor C1q and activate the C1 complex, leading to the formation of C3 convertase and the enzymatic cleavage of the central complement component C3. C3 then releases the chemotactic factor C3a and the covalent C3b attaches to the host cells, which is an important step for continued activation of the terminal membrane attack complex, C5b-9, and for the amplification through the alternative pathway. C5b-9 is thought to be. | AUTISM SPECTRUM DISORDERS - FROM GENES TO ENVIRONMENT Edited by Tim Williams Autism Spectrum Disorders - From Genes to Environment Edited by Tim Williams Published by InTech Janeza Trdine 9 51000 Rijeka Croatia Copyright 2011 InTech All chapters are Open Access articles distributed under the Creative Commons Non Commercial Share Alike Attribution license which permits to copy distribute transmit and adapt the work in any medium so long as the original work is properly cited. After this work has been published by InTech authors have the right to republish it in whole or part in any publication of which they are the author and to make other personal use of the work. Any republication referencing or personal use of the work must explicitly identify the original source. Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published articles. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the use of any materials instructions methods or ideas contained in the book. Publishing Process Manager Ivana Lorkovic Technical Editor Teodora Smiljanic Cover Designer Jan Hyrat Image Copyright Tatiana Popova 2010. Used under license from First published August 2011 Printed in Croatia A free online edition of this book is available at Additional hard copies can be obtained from orders@ Autism Spectrum Disorders - From Genes to Environment Edited by Tim Williams p. cm. ISBN 978-953-307-558-7 ikrrr iJ OPEN ACCESS INI Cvn PUBLISHER INTECH open free online editions of InTech Books and Journals can be found at .