tailieunhanh - Báo cáo y học: " Review of the use of Topiramate for treatment of psychiatric disorders"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Review of the use of Topiramate for treatment of psychiatric disorders. | Annals of General Psychiatry BioMed Central Review Open Access Review of the use of Topiramate for treatment of psychiatric disorders Danilo Arnone Address Department of Psychiatry Springfield University Hospital St George s Medical School London UK Email Danilo Arnone - Corresponding author Published 16 February 2005 Received 12 October 2004 . IAAF A p J I I I n rti-rtxz A I- Accepted 16 February 2005 Annals of General Psychiatry 2005 4 5 doi 1744-859X-4-5 This article is available from http content 4 1 5 2005 Arnone licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Topiramate is a new antiepileptic drug originally designed as an oral hypoglycaemic subsequently approved as anticonvulsant. It has increasingly been used in the treatment of numerous psychiatric conditions and it has also been associated with weight loss potentially relevant in reversing weight gain induced by psychotropic medications. This article reviews pharmacokinetic and pharmacodynamic profile of topiramate its biological putative role in treating psychiatric disorders and its relevance in clinical practice. Methods A comprehensive search from a range of databases was conducted and papers addressing the topic were selected. Results Thirty-two published reports met criteria for inclusion 4 controlled and 28 uncontrolled studies. Five unpublished controlled studies were also identified in the treatment of acute mania. Conclusions Topiramate lacks efficacy in the treatment of acute mania. Increasing evidence based on controlled studies supports the use of topiramate in binge eating disorders bulimia nervosa alcohol dependence and possibly in bipolar disorders in .