tailieunhanh - Báo cáo y học: "Fluoxetine: a review on evidence based medicine"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Fluoxetine: a review on evidence based medicine. | Annals of General Hospital Psychiatry Review Fluoxetine a review on evidence based medicine Andrea Rossi Alessandra Barraco and Pietro Donda BioMed Central Open Access Address Medical Dept. Eli Lilly Italia . via Gramsci 731 Sesto fiorentino Florence Italy Email Andrea Rossi - rossi_andrea_a@ Alessandra Barraco - barraco_alessandra@ Pietro Donda - donda_pietro@ Corresponding author Published 12 February 2004 Received 02 September 2003 Accepted 12 February 2004 Annals of General Hospital Psychiatry 2004 3 2 This article is available from http content 3 l 2 2004 Rossi et al licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Background Fluoxetine was the first molecule of a new generation of antidepressants the Selective Serotonin Re-uptake Inhibitors SSRIs . It is recurrently the paradigm for the development of any new therapy in the treatment of depression. Many controlled studies and meta-analyses were performed on Fluoxetine to improve the understanding of its real impact in the psychiatric area. The main objective of this review is to assess the quality and the results reported in the metaanalyses published on Fluoxetine. Methods Published articles on Medline Embase and Cochrane databases reporting meta-analyses were used as data sources for this review. Articles found in the searches were reviewed by 2 independent authors to assess if these were original meta-analyses. Only data belonging to the most recent and comprehensive meta-analytic studies were included in this review. Results Data based on a group of 9087 patients who were included in 87 different randomized clinical trials confirms that fluoxetine is safe and effective in the treatment of depression from the first week of therapy. Fluoxetine s main .