tailieunhanh - Báo cáo y học: "Birth order modifies the effect of IL13 gene polymorphisms on serum IgE at age 10 and skin prick test at ages 4, 10 and 18: a prospective birth cohort study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Birth order modifies the effect of IL13 gene polymorphisms on serum IgE at age 10 and skin prick test at ages 4, 10 and 18: a prospective birth cohort study. | Ogbuanu et al. Allergy Asthma Clinical Immunology 2010 6 6 http content 6 1 6 ALLERGY ASTHMA CLINICAL IMMUNOLOGY RESEARCH Open Access Birth order modifies the effect of IL13 gene polymorphisms on serum IgE at age 10 and skin prick test at ages 4 10 and 18 a prospective birth cohort study 1 1 1 23 Ikechukwu U Ogbuanu Wilfried J Karmaus Hongmei Zhang Tara Sabo-Attwood Susan Ewart Graham Roberts4 Syed H Arshad4 Abstract Background Susceptibility to atopy originates from effects of the environment on genes. Birth order has been identified as a risk factor for atopy and evidence for some candidate genes has been accumulated however no study has yet assessed a birth order-gene interaction. Objective To investigate the interaction of IL13 polymorphisms with birth order on allergic sensitization at ages 4 10 and 18 years. Methods Mother-infant dyads were recruited antenatally and followed prospectively to age 18 years. Questionnaire data at birth age 4 10 18 skin prick test SPT at ages 4 10 18 total serum IgE and specific inhalant screen at age 10 and genotyping for IL13 were collected. Three SNPs were selected from IL13 rs20541 exon 4 nonsynonymous SNP rs1800925 promoter region and rs2066960 intron 1 . Analysis included multivariable log-linear regression analyses using repeated measurements to estimate prevalence ratios PRs . Results Of the 1456 participants birth order information was available for 1212 1456 SPT was performed on at age 4 at age 10 and at age 18. The prevalence of atopy sensitization to one or more food or aeroallergens increased from at age 4 to at 10 and at age 18. Repeated measurement analysis indicated interaction between rs20541 and birth order on SPT. The stratified analyses demonstrated that the effect of IL13 on SPT was restricted only to first-born children p adjusted PR 95 CI . Similar findings were noted for firstborns regarding elevated total serum IgE at age 10 p .