tailieunhanh - Báo cáo y học: "The anti-inflammatory effects of levocetirizine - are they clinically relevant or just an interesting additional effect"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The anti-inflammatory effects of levocetirizine - are they clinically relevant or just an interesting additional effect? | Allergy Asthma Clinical Immunology BioMed Central Open Access Review The anti-inflammatory effects of levocetirizine - are they clinically relevant or just an interesting additional effect Garry M Walsh Address School of Medicine University of Aberdeen Aberdeen UK Email Garry M Walsh - Published 17 December 2009 Received 27 October 2009 .__ . . . r . Accepted 17 December 2009 Allergy Asthma Clinical Immunology 2009 5 14 doi l7l0-l492-5-l4 This article is available from http content 5 l l4 2009 Walsh licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Levocetirizine the R-enantiomer of cetirizine dihydrochloride has pharmacodynamically and pharmacokinetically favourable characteristics including rapid onset of action high bioavailability high affinity for and occupancy of the Hl-receptor limited distribution minimal hepatic metabolism together with minimal untoward effects. Several well conducted randomised clinical trials have demonstrated the effectiveness of levocetirizine for the treatment of allergic rhinitis and chronic idiopathic urticaria in adults and children. In addition to the treatment for the immediate shortterm manifestations of allergic disease there appears to be a growing trend for the use of levocetirizine as long-term therapy. In addition to its being a potent antihistamine levocetirizine has several documented anti-inflammatory effects that are observed at clinically relevant concentrations that may enhance its therapeutic benefit. This review will consider the potential or otherwise of the reported anti-inflammatory effects of levocetirizine to enhance its effectiveness in the treatment of allergic disease. Introduction The effects of histamine are .