tailieunhanh - Báo cáo khoa học: Emerging pathways in genetic Parkinson’s disease: Potential role of ceramide metabolism in Lewy body disease

Heterozygous loss-of-function mutations at the glucosecerebrosidase locus have recently been shown to be a potent risk factor for Lewy body disease. Based on this observation, we have re-evaluated the likelihood that the dif-ferent PARK loci (defined using clinical criteria for disease) may be misleading attempts to find common pathways to pathogenesis. | ỊFEBS Journal MINIREVIEW Emerging pathways in genetic Parkinson s disease Potential role of ceramide metabolism in Lewy body disease Jose Bras1 2 Andrew Singleton1 Mark R. Cookson3 and John Hardy4 5 1 Molecular Genetics Unit National institutes on Aging Bethesda MD USA 2 Center for Neuroscience and CellBiology University of Coimbra Portugal 3 CellBiology and Gene Expression Unit National institutes on Aging Bethesda MD USA 4 Department of Molecular Neuroscience Institute of Neurology University College London UK 5 Reta Lila Weston Institute and Department of Neurodegenerative Disease Institute of Neurology London UK Keywords ceramide gene glucocerebrosidase Lewy body loci mutation pathogenesis pathway risk factor susceptibility Correspondence J. Hardy Department of Molecular Neuroscience Institute of Neurology University College London Queen Square London WC1N 3BG UK Fax 44-0207-833-1016 Tel 44-0207-829-8722 E-mail Received 7 July 2008 revised 2 September 2008 accepted 25 September 2008 doi Heterozygous loss-of-function mutations at the glucosecerebrosidase locus have recently been shown to be a potent risk factor for Lewy body disease. Based on this observation we have re-evaluated the likelihood that the different PARK loci defined using clinical criteria for disease may be misleading attempts to find common pathways to pathogenesis. Rather we suggest grouping the different loci which lead to different Lewy body disease may be more revealing. Doing this we suggest that several of the genes involved in disparate Lewy body diseases impinge on ceramide metabolism and we suggest that this may be a common theme for pathogenesis. Parkinson s disease PD is a common neurodegenera-tive disease which affects over 1 of people over the age of 65 years 1 . Clinical manifestations include bradykinesia rigidity tremor and postural instability. From a pathological perspective PD is characterized by dopamine neuron .

• Báo cáo khoa học
• scientific reports
• medical reports
• health education
• immune system
• Antimicrobial
• biosynthesis
• Olea europaea
• Vitamin E biosynthesis
• Gene expression
• Tocopherol biosynthesis genes
• Synthesized in plants
• Mango malformation
• Transcriptomic analysis of Brassinosteroid biosynthesis
• Brassinosteroid biosynthesis
• Signaling pathway genes
• Malformed tissues
• Mango variety amrapalli
• Tartary buckwheat
• Jasmonate ZIM domain proteins
• Yeast two hybrid
• Anthocyanin biosynthesis
• Flavonoid biosynthesis
• Plant Biology
• Camellia sinensis
• Integrated transcriptomics
• Metabolomics analysis
• Theanine biosynthesis
• biochemistry
• molecular Biology
• Trypanosoma
• medical research
• breast cancer
• medicine
• Structural Biology
• intermediate cells
• metabolites
• biochemical studies
• Glutathionylspermidine is an intermediate formed in the biosynthesis of trypanothione
• an essential metabolite in defence against chemical and oxi dative stress in the Kinetoplastida
• The kinetic mechanism for glutathionyl spermidine synthetase (EC 6
• 8) from Crithidia fasciculata (CfGspS) obeys a rapid equilibrium random ter ter model with kinetic constants KGSH= 609lm
• KSpd= 157lmand KATP= 215lm
• scientific research
• oxidation
• cytoplasm
• biological cells
• Streptomyces
• molecular
• analysis of cytoplasmic
• hemoglobin
• Ebook Biochemistry
• Synthesizing themolecules of life
• The biosynthesis of amino acids
• The biosynthesis of membrane lipids
• Responding to environmental changes
• Sensory systems
• Tạp chí Đại học công nghiệp thực phẩm
• Effect of plant oils on mycelial biomass production
• Biosynthesis and antioxidants of exopolysaccharide
• Immunomodulatory and antitumor
• Demonstrated that exopolysaccharides
• Vietnam Journal of Science and Technology
• Rice bran oil on mycelial biomass production
• Biosynthesis and bioactivities of polysaccharides
• Ophiocordyceps sinensis fungus
• Rice bran oil
• Daucus carota
• MYB 6 and Restriction digestion
• Regulating Anthocyanin biosynthesis
• GFP Tagged MYB 6 Gene
• Aimed to clone GFP
• BMC Plant Biology
• P appendiculatum
• Flavonoids biosynthesis
• Basic helix loop helix
• Transcription factors
• Pyrus bretschneideri
• Stone cells
• Lignin biosynthesis
• Transcriptomic analysis
• Cinnamoyl CoA reductase
• Solanum melongena L
• High temperature
• BMC Biotechnology
• Tribolium castaneum
• RNA interference
• Chitin biosynthesis pathway
• Gene function
• Gossypol biosynthesis
• Plant grafting
• Organ culture
• Gene expression profiling
• RNA seq
• Ester biosynthesis
• Transcriptional regulation
• Ripening fruit
• Amaryllidaceae alkaloid
• Pathogenesis related protein 10
• Alkaloid biosynthesis
• Narcissus pseudonarcissus
• Norcoclaurine synthase
• Inflorescence architecture
• BRs biosynthesis
• Panicle architecture
• PMM1 transcripts
• Tissue acidification
• Litchi chinensis
• Rubber biosynthesis
• Parthenium argentatum
• Hevea plantations