tailieunhanh - Báo cáo y học: "Nature of Regulatory T Cells in the Context of Allergic Disease."

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Nature of Regulatory T Cells in the Context of Allergic Disease. | ORIGINAL ARTICLE Nature of Regulatory T Cells in the Context of Allergic Disease Cevdet Ozdemir MD Mubeccel Akdis MD PhD and Cezmi A. Akdis MD Allergen-specific immunotherapy SIT is the cornerstone of the management of allergic diseases which targets modification of the immunologic response along with environmental allergen avoidance and pharmacotherapy. SIT is associated with improved tolerance to allergen challenge with a decrease in immediate-phase and late-phase allergic inflammation. SIT has the potential to prevent development of new sensitizations and progression of allergic rhinitis to asthma. It has a role in cellular and humoral responses in a modified pattern. The ratio of T helper Th 1 cytokines to Th2 cytokines is increased following SIT and functional regulatory T cells are induced. Interleukin-10 production by monocytes macrophages and B and T cells is increased as well as expression of transforming growth factor p. SIT is associated with increases in allergen-specific antibodies in IgA IgG1 and IgG4 isotypes. These blocking-type immunoglobulins particularly IgG4 may compete with IgE binding to allergen decreasing the allergen presentation with the high- and low-affinity receptors for IgE FceRI and FceRII respectively . Additionally SIT reduces the number of mast cells and eosinophils in the target tissues and release of mediators from these cells. Key words dendritic cells mucosal tolerance regulatory T cells allergen-specific immunotherapy rhe allergic immune response is directed against various environmental allergens and manifests clinically as allergic rhinitis allergic asthma food allergy allergic skin inflammation ocular allergy and or anaphylaxis. Contact of an allergen with the immune system starts with handling of it by the antigen-presenting cells mainly dendritic cells DCs which process antigenic material and present it on its surface to other cells of the immune system especially to CD4 T helper Th 2 cells. This results in Th2-type .