tailieunhanh - Báo cáo y học: "The Mind-Body of Allergic Diseases"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The Mind-Body of Allergic Diseases. | INTRODUCTION The Mind-Body of Allergic Diseases rhe nature of the relationship between the mind and the body has preoccupied philosophers and physicians for centuries. In current discussions of health and disease this subject and its implications for well-being are frequently pointed out in the media and are of great interest to the public. For example contemporary thinking concerning the increasing prevalence of chronic inflammatory diseases such as allergic asthma bases itself on the assumption that psychological stress via neuroendocrine and immunologic networks and changes in homeostasis can influence lung function and thus expression of disease. There is indeed evidence that stress can induce attacks of asthma and may also cause asthma to develop. Unfortunately the literature in these fields is large complex and often confusing. Nonetheless we are quickly gaining a broader understanding of some of the cellular and molecular mechanisms that mediate environmental perturbations through stress to cause dysregulated physiologic responses eventuating in chronic inflammatory diseases such as allergies. Stressful stimuli early in life can have long-lasting impacts on mind-body pathways and physiologic and pathophysiologic responses later in life. Recent discoveries have shown that stress-related epigenetic changes and associated alterations in gene expression in early even fetal life can lead to long-lasting impacts on adult health and disease such studies may identify novel therapeutic pathways and targets for control of many chronic diseases. It is becoming clear that a more thorough understanding of the nature and extent of mind-body pathways is essential if we are to develop novel and effective management strategies for allergic and other chronic diseases. As part of a rigorous participatory process to identify fundamental gaps in our knowledge and to develop a strategic research plan AllerGen NCE Inc. a recently funded Canadian Network of Centres of Excellence .