tailieunhanh - Báo cáo y học: "Interleukin-12 Peripheral Blood Levels in Asthmatic Children"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Interleukin-12 Peripheral Blood Levels in Asthmatic Children. | ORIGINAL ARTICLE Interleukin-12 Peripheral Blood Levels in Asthmatic Children Ruth Soferman MD Idit Rosenzwig MD and Elizabeth Fireman PhD Interleukin-12 IL-12 was measured in 45 asthmatic children aged 3 to 16 years. The assessments were performed on 20 children during an episode of acute exacerbation and on 25 children during remission. There was no significant difference between the mean IL-12 level during exacerbation pg mL and during remission pg mL p 5 .83 . A positive but insignificant correlation was found between forced expiratory volume in 1 second and IL-12 p 5 .634 . IL-12 levels were significantly lower in children with a positive family history of asthma pg mL compared with those without pg mL p .012 supporting the theory that the gene-environment interactions affect the immune responses. IL-12 peripheral blood levels had no detectable impact on the course of established asthma in the study population. Keywords asthma family history IL-12 rhe prevalence of atopic asthma a T helper Th 2-dependent disease is reaching epidemic proportions possibly owing to improved hygiene in industrialized The chronic inflammation of the airways in asthma is characterized by the presence of Th2 cells in sputum bronchoalveolar lavage and mucosal biopsy specimens 2 and the dominance of Th2 cells is responsible for the pathogenesis of allergic The priming of T cells requires the activation of dendritic cells DCs 7 which are generally considered to be the principal antigenpresenting cells APCs involved in the generation of polarized effector DCs have a major influence on the pattern of Th1 Th2 polarization by releasing cytokines especially interleukin-12 IL-12 .5 The route of the antigen encounter with the DC and the subtype of the APC can profoundly influence Th IL-12 the critical Thl-polarizing cytokine8 produced by DCs after stimulation by various antigens including the endotoxin .