tailieunhanh - Báo cáo y học: " Nonsteroidal Anti-Inflammatory Drug Hypersensitivity in Preschool Children"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Nonsteroidal Anti-Inflammatory Drug Hypersensitivity in Preschool Children. | ORIGINAL ARTICLE Nonsteroidal Anti-Inflammatory Drug Hypersensitivity in Preschool Children Mona lancovici Kidon Liew Woei Kang Chiang Wen Chin Lim Siok Hoon and Van Bever Hugo Although extensively studied in adults nonsteroidal anti-inflammatory drug NSAID hypersensitivity in children especially in young children remains poorly defined. Pediatricians prescribing antipyretics for children rarely encounter significant problems but the few epidemiologic studies performed show conflicting results. Although it is clear that some patients with acetylsalicylic acid ASA -sensitive asthma have their clinical onset of disease in childhood and bronchoconstriction after ASA challenge is seen in 0 to 22 of asthmatic children so challenged ibuprofen at antipyretic doses may cause acute respiratory problems only in a very small number of mild to moderate asthmatics. The recently elucidated mechanism of action of acetaminophen may explain some occurrences of adverse reactions in patients with cross-reactive NSAID hypersensitivity on the basis of its inhibitory activity on the newly described enzyme cyclooxygenase COX -3. This nonspecific sensitivity to inhibition of COX is most likely genetically determined and shows a remarkable association with atopic disease even in the very young age group and possibly an increased predilection in specific ethnic groups. This review summarizes state-of-the-art published data on NSAID hypersensitivity in preschool children. Key words acetaminophen acetylsalicylic acid ASA children hypersensitivity ibuprofen NSAID preschool Acetylsalicylic acid ASA and other nonsteroidal antiinflammatory drugs NSAIDs are a group of medications with heterogenic chemical structures sharing the capability of inhibiting with various degrees of specificity and efficacy the cyclooxygenase COX enzymes responsible for the prostaglandin synthetase pathway of arachidonic acid metabolism. This blockade also results in the shunting of arachidonic acid toward the .

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